I have seen articles with some positive information about rapamycin helping with vascular malformations, but not any specific information about its ability to help with varicose veins in particular. It would seem to me to make sense that its anti-inflammatory and autophagic properties could be of help in slowing the progression of varicose veins. Does anybody have any insight if there is any benefit of weekly dosing of rapamycin on varicose veins?
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I haven’t seen that benefit in over 2 years of weekly (then fortnightly) rapa use. Maybe it just takes another year. 
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Thank you for the information!
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Hey Tommy,
My mom had varicose veins really bad. Super noticeable. She was very embarrassed to wear a swimsuit.
So, when I started getting them mid-50’s… I was not happy about it.
Almost immediately on rapamycin, 3 to 6 months the varicose veins reduced in thickness… bumpiness. And, seemed to shrink in size…coloration too. In past 4. 5 years… no further development. Not noticeable.
Pic took just now.
Pics from April 2021. They had already reduced from 6 months of rapamycin. Sorry I don’t have a baseline… but you can see the difference and no progress in almost 4 years.
I actually took these pics in April 2021 because I was impressed with the improvement from rapamycin at the time… 4 years later… even better. No progression at all.
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Wow, that’s pretty incredible. Frankly when I saw this thread, I didn’t think rapamycin would have any affect on varicose veins, other than lower the inflammation in the affected veins. But to actually shrink them… I’m gobsmacked! These pics are pretty incredible. Btw., I bet you do have baseline pics - just obviously taken inadvertantly… we all get photographed so often, odds are there is a picture somewhere of you by a swimming pool, on a beach or the like where the relevant areas can be zoomed into🤣.
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Incredible ! Your self experimentation and experience are infinitely more helpful than Brian Johnson’s when it comes to longevity treatment.
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Thanks Bart… I truly think rapamycin can do wonders in repairing damage and regression to some extent. Two undeniable reversals are DEXA scans 2 years apart (taurine my be helping in these cases) from osteopenia to normal. And, periodontal disease from 4 areas of 4 level pockets- decay in one year…back to 3’s… now my whole mouth is normal.
This just in a few days ago from GlycanAge my inflammation is that of someone 21 years younger… no arthritis. My only spike in flammation was due to …too much rapamycin for 7 months… thanks “More is better… Dr. Blagosklonny” - lol. Otherwise 4 years measurements of excellent reversal… that has continued. 67 years in 3 months. Feeling like 40’s again.
I try to keep records of improvements, problems… or just stablity. Showing what is happening in my N=1 world.
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There you go! Amazing. Well, there are non-responders to rapamycin, negative-responders, and you are a super-responder, seemingly. Rapamycin looks like a really good drug for you! If it were being promoted commercially, you’d be on the poster, lol!
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Yes… reading for 4-years as a rapa member…there is a range of experiences for those on rapamycin. Fortunately benefits seem to be the norm.
My heart hurts when someone on here tries… hoping for the best and then has a very negative result. Blood type… phenotype… genetics… and lifestyle can all be wildcards for wins and losses.
It’s been a life changer for me.
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I think people at times ignore the need to have a properly functioning mTOR at times. I am close to taking another high dose, but there have been lots of viruses floating around. Yesterday I had a sore throat for about 6 hours. My WBC is now reliably above 2G, but it strikes me that taking an immune system suppressent when there are lots of infections is ill advised.
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Wow, those are impressive results! The improvements in the veins were pretty dramatic.
Great to see that!
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My hunch is that I get solid results on rapamycin because I started before the second aging effect of 60 settled in.
The belief is we age the most at 40 years and 60 years… I was already hitting gym hard… getting my testosterone up… TRT before I hit 60. So may have bought a few years for rapamycin to kick in… and push back the functional declines and disease.
I noticed the biggest varicose vein reduction in that first year… 6 mg rapamycin weekly.
But, then it stopped varicose vein progression.
Rapamycin is noted for helping with circulatory issues… and birthmarks… like facial port wine birthmarks… that are blood related and hard to get rid of… keeps coming back. But with rapamyacin the treatment works permanently.
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John you are right about the need for MTOR activation. You can’t stymie it without negative effects. When I went high… it aged my inflammation and biological age 10 years faster.
This could explain why Bryan Johnson dumped rapamycin… with all he is doing in starvation diet… cooling his body… over exercising… and who knows what else… with his higher than average dose of rapamycin… he probably stopped his MTOR completely… so MTOR2 can’t be produced.
So he decides to quit rapamycin… or he could keep rapamycin and stop everything else … his Blueprint.
The profitable choice is obvious keep Blueprint. But, he poo-poo’s rapamycin as a total negative… and then gives it bad press. Unfortunate for average normal folks.
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