I’ve slowly increased my dose from 3 or 4 mg 2 years ago, to 15mg to 20 mg every 10 days or so. Generally I think things have trended positively with dose. I think there may be an argument that rapamycin helps create a more youthful sleep phenotype. But - in my case, I had to stop using my sleep tracking Fitbit (actually the Amazon Halo Fitness band) because as I got higher in dose, I started to get recurring contact dermatitis rash under the band - so I’m no longer tracking my sleep or even wearing anything on my wrist. No more rash now!.
3 Likes
It will take me a little while to digest that article.
1 Like
Try tea tree oil for the contact dermatitis from wearing a sleep tracking wristband. It works.
1 Like
Tea tree oil has antibacterial properties and will prevent any infection on the skin.
1 Like
At a 6 mg dose once weekly for 3 months I’ve noticed no effect on sleep so far.
1 Like
How was your sleep before taking rapamycin?
Do you practice any sleep hygiene ?
How was your sleep before even taking rapamycin, and how was your sleep hygiene.
I slept well before I began Rapa. I sleep somewhat less now but at 72 i know that’s normal
4 Likes
Great question, and one that hopefully will be researched. For several years, I have had interrupted sleep, not being able to sleep deeply, continuously, throughout the night. I was hoping that, since sleep quality tends to decline with aging, Rapamycin would restore a more youthful sleep pattern. I have been taking 6mg Sirolimus once weekly, but it has only been one month. I have not noticed any changes in my quality of sleep. I will post an update if I experience any changes after 3 months.
3 Likes
Rapa definitely affected my sleep. I take 6mg early Friday mornings and am wired through half-life. My cardiologist also takes rapa (as do more than half the docs in his office) and he gave me an Ambien scrip… I break one in half for use on Fri and Sat nites and take a 2mg time-release melatonin for the next couple nites. I actually look forward to weekends sleep now.
4 Likes
Woah, Ambien? Rapamycin must really keep you up then lol.
Thanks
2 Likes
Perhaps TMI:
As I am an “elderly” person, ~81 yrs old, I have suffered from age-related sleep problems for the last 20 yrs. My main problem is not going to sleep but remaining asleep for 6 - 8 hours.
I have tried many “sleep stacks” and here are my subjective results of the ones I am currently using every day or periodically:
Melatonin is a must. Other supplements, OTCs, etc.:
Trazadone: 50 mg: Originally developed as an anti-depressant, but has proven to be more effective as a sleep aid. (If your physician won’t prescribe, you can also get these from many sources in India quite cheaply.) Trazadone has proven to be my most reliable “supplement” for staying asleep. It is generally considered safe for long-term use and is not addictive.
Kirkland Signature Sleep Aid Doxylamine Succinate 25 Mg. I only use this when I am overstimulated and have trouble going to sleep. This is not a good supplement for regular use, especially for older people. (Of course, older people are its main users. LOL)
Tryptophan: helps with staying asleep, plus has some antidepressant effects and is also a weak NAD+ precursor.
Glycine: Sleep aid, plus longevity effects.
I have also tried Ambien and love it. It provides me with a “clean” night’s sleep with no morning after effects. Unfortunately, it is not good or safe for long-term use.
TRAZADONE:
Trazodone for Insomnia: A Systematic Review:
“This review article has found that trazodone can be an effective option when treating insomnia with little to no risk in most cases”
Treatment of insomnia – effect of trazodone
and hypnotics on sleep:
“It should be noted that low doses of trazodone
(50 mg) do not increase, but rather decrease, daytime sleepiness and have no negative
effect on the ability to drive vehicles.”
“A special feature of trazodone, mianserin, and mirtazapine is their ability to
increase the amount of deep sleep.”
http://www.psychiatriapolska.pl/uploads/images/PP_4_2021/ENGver743Wichniak_PsychiatrPol2021v55i4.pdf
The effects of trazodone on human cognition: a systematic review"
Overall, seven studies showed no effect of trazodone on cognition, five showed a beneficial effect by improving or reducing cognitive decline, and four evidenced impaired cognitive function. Our analysis highlights the possibility of a dose-independent dual effect of trazodone on human cognition.
Effects of Trazodone on Sleep Quality and Cognitive Function in Arteriosclerotic Cerebral Small Vessel Disease Comorbid With Chronic Insomnia
8 Likes
i take the usual 5mg once a week (well, every 1-2 weeks i’m not super consistent). My oura ring before rapamycin put me at an average of 50 mins deep sleep a night. After rapamycin, i’d say it’s more like 1:15 average deep sleep. But then it could be that I have the new Oura ring as well. But I def feel like I’m getting more deep sleep. I’m 56 and generally healthy.
5 Likes
Just started 2Mg a week last week. Took first dose mid-morning and definitely felt sleep disturbance first night. Rest of week was fine. I am typically a good sleeper and use ‘sleep tracker’ every night. That first night I scored a 67 and usually am north of 80. Today I took 3mg, with grapefruit juice, as a step on the way to 6mg a week. I plan to take a melatonin supplement before bed tonight. We’ll see.
5 Likes
I found I had a little sleep disturbance if I took rapamycin in the afternoon - so now I just take it first thing in the mornings - and the problem has gone away.
3 Likes
I have been taking Rapamycin for 2 months weekly. I track sleep with an Oura ring. There has been no difference in my quality or quantity of sleep. Subjectively I don’t feel any effects on my sleep not even around the day of dosing.
4 Likes
For those who are experiencing some sleep disturbance I would suggest skipping coffee on the day you take your dose as they seem to have an additive effect.
1 Like
For what it is worth Melatonin did the trick. Slept fine even with the bigger dose.
3 Likes
Hi…a couple studies in mice have reported treatment with rapamycin reduces sleep fragmentation…nothing in the literature regarding effects on sleep for humans. My personal experience…I have always slept well and haven’t noticed any change one way or the other since taking rapamycin for the past 9 months.
3 Likes