Seems that there is still a greater risk of developing skin cancer with rapamycin. I will now stop taking it until I possibly feel more comfortable with this. how have you reasoned given that?
Can you post links or citations of studies showing rapamycin as promoting or causing skin cancer? Perhaps this is dose dependent, because if there is immune suppression at very high doses or dose+duration, maybe that’s something that happens.
Otherwise it seems the signal is often in the opposite direction:
But it would be interesting to see evidence either way.
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I have genes for malignant melanoma risk and had UVB ‘treatment’ for acne in the late 1970s so Im aware of my risks. However I wasnt aware that Rapa might be a risk; in fact Id assumed the opposite.
To offset this I take Astaxanthin and Polipodium and occasional cycles of IP6 as prevention strategies.
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As I believe I mentioned elsewhere, shortly after my first few doses of rapamycin, a small, 40 year old mole on my back changed color, became crusty, and bled if I scratched it inadvertently. A shave Dx revealed squamous cell carcinoma. I had the margins excised.
I have no way of knowing if the rapamycin played a causal role, acted as an accelerant, or played no role in this case but given the 30-40 year stability of the mole with no sun exposure in at least that same time, I decided to stop taking rapamycin. I do recall 20 years ago a friend who had a kidney transplant due to a rogue virus attack, was cautioned to shield his skin from the sun at all times. He was an outdoors guy so it was tough on him to wear long sleeved shirts, big brimmed hats, etc. but his doctors insisted on it.
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Where do you buy your polypodium?
This is one (I think the first commercial product, not 100% sure about that though):
I took it for awhile but had doubts about efficacy. My dermatologist poo-pooed it. So I don’t know.
Amazon. Company called Supersmart. No idea about potency though
I had the same professional response. Although Sandy Kaufman was pretty bullish about Astaxanthin if I remember correctly. Was in her early protocol, before Miller’s ITP findings
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What do you mean by this? Why?, how much? How often?
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seems to be the case according to several studies that rapamycin reduced the incidence of skin cancer in transplant recipients, but that the risk of being affected when you take rapamycin is still increased. then it is true that many studies apply to transplant recipients with completely different doses, so a schedule of once a week is perhaps something else. it therefore depends on a certain amount of theorizing and taking chances on risks. many studies also refer to mice so that also makes this uncertain when it comes to humans.
IP6 is inositol hexaphosphate. Slowed cancer progression in animal studies. Said to be an mTOR inhibitor too. Lots of anecdotal stories about individuals with Ca who inhibited tumour progression. I cycle IP6 Gold
Doctor Sandra Kauffman recommended that one too, fern block yes. I can tell you since I heard about it, I take it for over 1 year. When I go on sunny holidays or just when the sun out for a few days on a row. I take it with astaxanthin of course, never got sunburn. I’m careful with that anyway. I give it to my husband and 2 boys and they don’t either but the best with it, it’s I double the dose when I see a bit of red on the boys, youngish 10, and it just goes and no pain or complaints about it. You can’t be protecting children 24h a day under the sun when they re just being children playing outside. That’s the best proof for me!
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