Rapamycin and probiotics?

#1

If you do take probiotics/prebiotics, how do you use it with rapamycin? I remember someone saying (probably Matt Kaeberlein / Peter Attia, I’ll provide a link later) that rapamycin can potentially reduce gut lining. Are probiotics/prebiotics more useful when the stomach lining is intact, or when it is depleted?

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#2

I missed this, if it was mentioned in a Kaeberlein/Attia podcast. If you find out more, please post it.

#3

Maybe it was David Sabatini, but my search skills are letting me down.

However here’s a snippet from a Blagosklonny paper:

rapamycin may cause stomatitis and mycositis (ulceration of the mucous membranes of the mouth and the digestive tract) when used at high doses or chronically.

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#4

With all the different probiotics on the market, I’m not knowledgeable of the best form to take. Anyone recommend a good brand/product and if so could you provide link and tell me why this one is a good one? Thank you.

#5

I use 3 high dose probiotic strains daily (on an empty stomach in the morning):

  1. BB-12, 25 billion CFU/day from Optibac’s Bifido and Fiber ( https://www.optibacprobiotics.com/uk/product/bifidobacteria-fibre-30-sachets, I order from their UK site during their periodic 25% sales), taken with 600mg Arginine-Base to encourage formation of Spermidine in Gut.
  2. Akkermansia, 30 billion TFU/day from Akkermansia Company (ordered from Fullscript using a 25% discount) : These are pasteurized (dead) bacteria, taken for the nutritional benefit (blood sugar lowering and life extension).
  3. Customs Probiotics 11-strain mix powder (https://www.customprobiotics.com/custom-probiotics-11-strain.html): I take 0.8g/day, corresponding to 200 billion CFU/day (increased to 1 trillion CFU/day when taking antibiotics or DAV therapy). This is a small Los Angeles company that has the lowest cost bulk Probiotics when you need 200+ billion CFU/day.
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