Rapamycin and NMN

I was curious about any possible conflict between Rapamycin and NMN, I asked Google Bard (Take this with a grain of salt) Here is what she said:

are there any studies that show health benefits from rapamycin in combination with NMN

Yes, there is growing evidence that suggests that rapamycin and NMN may have synergistic health benefits when taken together. Several studies have shown that the combination of these two compounds can improve lifespan, reduce the risk of age-related diseases, and enhance overall health and well-being.

Animal Studies

  • A study published in the journal “Aging Cell” found that mice treated with both rapamycin and NMN had a 20% increase in lifespan compared to mice treated with either compound alone. The study also found that the combination of rapamycin and NMN improved the health of the mice’s hearts, muscles, and brains.

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Rapamycin in combination with NMN study

  • A study published in the journal “PLOS One” found that mice treated with both rapamycin and NMN had a reduced risk of developing cancer. The study also found that the combination of rapamycin and NMN improved the mice’s immune system function.
  • A study published in the journal “Nature Medicine” found that mice treated with both rapamycin and NMN had improved mitochondrial function. Mitochondria are the powerhouses of the cells, and they play a critical role in aging.

Human Studies

  • There are a few small human studies that have investigated the effects of rapamycin and NMN. One study found that rapamycin improved insulin sensitivity in people with type 2 diabetes. Another study found that NMN improved cognitive function in older adults.
  • While more research is needed to confirm the benefits of rapamycin and NMN in humans, the existing evidence suggests that these compounds may have a promising future in anti-aging medicine.

Potential Mechanisms of Action

The potential mechanisms of action for the synergistic effects of rapamycin and NMN include:

  • Rapamycin inhibits the mTOR pathway, which is involved in cell growth and aging. NMN increases NAD+ levels, which are important for cellular energy production and DNA repair.
  • Rapamycin and NMN may work together to activate sirtuins, which are a group of proteins that have been shown to promote longevity.
  • Rapamycin and NMN may also work together to reduce inflammation, which is a major contributor to aging and age-related diseases.

It is important to note that both rapamycin and NMN are powerful compounds and can have side effects. Rapamycin can suppress the immune system, and NMN can cause mild stomach upset. It is important to talk to your doctor before taking either of these compounds.

Overall, the research on rapamycin and NMN is still in its early stages, but the existing evidence suggests that these compounds may have potential as anti-aging therapies. More research is needed to determine the safety and efficacy of these compounds in humans.

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I suspect the referenced studies are hallucinations… try to get it to specify the exact studies so we can look them up… and see if they actually exist.

When I did this sort of thing with ChatGPT it had a nasty tendency to just make up paper references.

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  • “A study published in the journal “Aging Cell” found that mice treated with both rapamycin and NMN had a 20% increase in lifespan compared to mice treated with either compound alone.”

Does it have something to do with this?

Was this already discussed here at some point? Maybe I missed it.

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Here is what Bard said when I asked for references:

  1. “Rapamycin and Nicotinamide Mononucleotide Extend Mouse Lifespan through the mTOR Pathway”

Authors: Chen, D., et al.

Journal: Aging Cell

Year: 2020

Link: Rapamycin’s Improvement of Muscle Cell Metabolic Balance May Enhance Longevity

  1. “Nicotinamide Mononucleotide Supplementation Attenuates Cancer Development and Enhances Immune Function in Mice”

Authors: Liu, Y., et al.

Journal: PLOS One

Year: 2018

Link: Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns - PMC

  1. “Nicotinamide Mononucleotide Enhances Mitochondria Function and Protects against Age-Associated Diseases”

Authors: Fang, V., et al.

Journal: Nature Medicine

Year: 2020

Link: Nicotinamide Mononucleotide Supplementation Improves Mitochondrial Dysfunction and Rescues Cellular Senescence by NAD+/Sirt3 Pathway in Mesenchymal Stem Cells - PMC

  1. “Rapamycin Improved Insulin Sensitivity in Patients with Type 2 Diabetes”

Authors: Kalender, M. E., et al.

Journal: Journal of Clinical Endocrinology and Metabolism

Year: 2012

Link: Differential Effects of Rapamycin on Glucose Metabolism in Nine Inbred Strains | The Journals of Gerontology: Series A | Oxford Academic

  1. “Nicotinamide Mononucleotide Improves Cognitive Function in Older Adults”

Authors: Zhang, H., et al.

Journal: Journal of the American Geriatrics Society

Year: 2018

Link: Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice - PubMed

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