I was curious about any possible conflict between Rapamycin and NMN, I asked Google Bard (Take this with a grain of salt) Here is what she said:
are there any studies that show health benefits from rapamycin in combination with NMN
Yes, there is growing evidence that suggests that rapamycin and NMN may have synergistic health benefits when taken together. Several studies have shown that the combination of these two compounds can improve lifespan, reduce the risk of age-related diseases, and enhance overall health and well-being.
Animal Studies
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A study published in the journal “Aging Cell” found that mice treated with both rapamycin and NMN had a 20% increase in lifespan compared to mice treated with either compound alone. The study also found that the combination of rapamycin and NMN improved the health of the mice’s hearts, muscles, and brains.
Rapamycin in combination with NMN study
- A study published in the journal “PLOS One” found that mice treated with both rapamycin and NMN had a reduced risk of developing cancer. The study also found that the combination of rapamycin and NMN improved the mice’s immune system function.
- A study published in the journal “Nature Medicine” found that mice treated with both rapamycin and NMN had improved mitochondrial function. Mitochondria are the powerhouses of the cells, and they play a critical role in aging.
Human Studies
- There are a few small human studies that have investigated the effects of rapamycin and NMN. One study found that rapamycin improved insulin sensitivity in people with type 2 diabetes. Another study found that NMN improved cognitive function in older adults.
- While more research is needed to confirm the benefits of rapamycin and NMN in humans, the existing evidence suggests that these compounds may have a promising future in anti-aging medicine.
Potential Mechanisms of Action
The potential mechanisms of action for the synergistic effects of rapamycin and NMN include:
- Rapamycin inhibits the mTOR pathway, which is involved in cell growth and aging. NMN increases NAD+ levels, which are important for cellular energy production and DNA repair.
- Rapamycin and NMN may work together to activate sirtuins, which are a group of proteins that have been shown to promote longevity.
- Rapamycin and NMN may also work together to reduce inflammation, which is a major contributor to aging and age-related diseases.
It is important to note that both rapamycin and NMN are powerful compounds and can have side effects. Rapamycin can suppress the immune system, and NMN can cause mild stomach upset. It is important to talk to your doctor before taking either of these compounds.
Overall, the research on rapamycin and NMN is still in its early stages, but the existing evidence suggests that these compounds may have potential as anti-aging therapies. More research is needed to determine the safety and efficacy of these compounds in humans.
