Rapamycin and Niacin combination induces apoptosis and cell cycle arrest through autophagy activation on acute myeloid leukemia cells

#1

Background

Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy caused by disorders in stem cell differentiation and excessive proliferation resulting in clonal expansion of dysfunctional cells called myeloid blasts. The combination of chemotherapeutic agents with natural product-based molecules is promising in the treatment of AML. In this study, we aim to investigate the anti-cancer effect of Rapamycin and Niacin combination on THP-1 and NB4 AML cell lines.

Conclusion

Although further studies are required, the combination of Rapamycin and Niacin combats cell proliferation by inducing cellular apoptosis, cell cycle arrest and autophagy activation.

Paywalled paper:

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#2

Yesterday night, I received bad news that a friend of mine (70yo) is now at end stage Acute Myeloid Leukemia (AML). The doctor has now said he has 2-3 weeks left.

It happened so quickly, he was admitted to hospital on Christmas eve and has not been out since.

Is the above drug combination something worth suggesting to the doctor?

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#3

I can’t read the paper as its behind a paywall, but what do you have to lose? So sorry to hear about your friend.

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#4

Try it as a Hail Mary attempt. There’s nothing to lose IMHO.

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