I’ve heard that Rapamycin intefears with the effects of Ketamine, because some of the effects that Ketamin has are interupted by inhibiting the mTORC1 pathway, where Ketamine’s action realies on interfering with the downstream pathway activities of this pathway, which basically gets turned off.
I’m guessing this could also explain the ulceration seen in the bladders of chronic Ketamine users; is Ketamine’s interference in the latter parts of this pathway perhaps inhibiting the rate of cellular turnover in the blader? In the same way Rapamycin can cause mouth ulcers, by posissbly inhibiting cell turnover in the mouth.
Can anyone provide more detials on how Rapamycin interfears with Ketamine’s actions and how Ketamine interacts with the same pathways Rapamycin interacts with?