I wonder if rapamycin might have its effects on muscle aging through ceramide inhibition? Anyone more familiar on this topic, and whether there are any natural ceramide inhibitors?
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I take 6mg Rapa with Evoo, 500mg Metformin and 50mg Acarbose Monday morning and wait until Wednesday morning before I do my first of three WL weekly sessions. Monday and Tuesdays I try to keep my protein intake low and avoid insulin spikes in order to maximize mTOR inhibition. Pre Rapa, every morning, I used to do a 20min 180 degrees Fahrenheit sauna session followed by cold plunge.
It seems that Sauna increases autophagy but at the same time increases mTOR and protein synthesis, but on the positive side cold water reduces mTOR activity.
As my morning sauna + cold plunge session has such a positive impact on the rest of my day, I would very much appreciate any insights or advice 
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I’ve put on muscle while on 4mg of rapamycin for 3 months. It’s very posible that I could have put more had I not been on it, but the point remains : its possible to put on muscle mass while on rapamycin. See
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My lean body mass has increased by 3% just from reading Agetron posts. I admit that my rapamycin use is a confounding factor in my N equals one.
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I’m curious and look out for rapamycin and ceramide interactions too. But in the meanwhile, this is out, on using myriocin for ceramide inhibition on aged mice: https://scitechdaily.com/researchers-identify-a-new-hallmark-of-aging/
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Zazim : My lean body mass has increased by 3% just from reading Agetron posts.
Hahaha… what helped??? Curious.
Was in the gym today with a Marine buddy… beast of a guy… 240 pounds 6ft. 4 in.
I told him his mass is enviable.
His reply was … trade it for your shredded look.
So there it is.
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Osmosis!
Reaching 20 characters
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Channeling health and fitness your way fellow guinea pig. 
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Thanks for sharing, great data. Do you work out on days taking Rapa ?
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No, not typically (though I haven’t detected any differences when I do).
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I monitor all of these things closely. No change in resting heart rate since starting rapamycin and no change in resting heart rate on the day I take rapamycin and the day following. Similar results for HRV. No change.
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Some report anecdotally that they feel strong and can have vigorous workouts when they hit the gym after having taken rapamycin. Others report anecdotally they feel weak in the gym the days/the week after taking rapamycin.
There is mTOR independent protein synthesis that is not inhibited by rapamycin. Citrulline is one substance that,might be beneficial for muscle building when in mTOR inhibited state. Why? One can speculate that it is due to increased muscular perfusion and subsequent oxygen utilization? This might also be the mechanism by Viagra that keeps the brain younger and less prone to alzheimers. According to this “logic” it might be a good idea to use citrulline before going to the gym after taken rapamycin.
In vitro:
http://aups.org.au/Proceedings/44/13P/13P.pdf
“In conclusion, L-citrulline preserves rates of protein synthesis and protects myotubes from wasting in a different manner than L-arginine. We demonstrate a novel direct protective effect of L-citrulline on protein metabolism and skeletal muscle cell size that is not mediated by signaling through the mechanistic Target of Rapamycin. Instead, we show these effects are mediated through the inducible NOS (iNOS) isoform. This is the first study to describe a nutritional modulator of iNOS mRNA expression by skeletal muscle cells and could have important implications for the treatment of muscle wasting conditions.
“L-CIT may improve exercise capacity by upregulating muscular perfusion and subsequent oxygen utilization.” “In addition, the action of L-CIT on muscle function also is related to its ability to promote muscle protein synthesis. “ “Future research is still needed to decipher the contribution of endothelial versus neuronal NO production to the vascular and muscular benefits observed after L-CIT supplementation”
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How does this result correspond with your rapamycin protocol?
I felt that dosages of 8mg+ were negatively affecting my performance so switched to a more conservative 5mg/week in December. As you can see, I am now performing at close to my best all time level despite only doing 6 hours per week.
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Dose is important… higher doses for me were not great… 6mg plus GFJ.
Now doing 2mg and GFJ. Will have new testing done in a few weeks.
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I’m 56, male, and I take 5 mg Rapa once a week on Monday and do workouts on my Tonal from Monday - Friday. My protein intake is highest at breakfast and dinner and at 150 lbs, I try for 1.6 mg/kg of protein daily. I also take exogenous testosterone (I have hypogonadism) and am experimenting with peptides.
I see consistent gains in strength and lean muscle mass with regularity and have a body fat content of 14%. I don’t do Metformin at all. I honestly feel my best the 2 days following Rapa dosing, but can’t say I ever feel fatigued by the weekend. I follow my stats pretty closely and other than my cholesterol going up the only thing my doc noticed is that my kidney function has improved, to the point where he was surprised at the results. The nice thing about the Tonal is it tracks all of your output, strength gains, reps and charts the improvements for me, so I know the gains are real. Between that and the biometric scale I truly believe that Rapa has done nothing to inhibit my gains.
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My workouts, virtual cycling are intense, and pretty sure my max heart rate has gone up since Rapamycin. Getting even healthier.
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I just wish l-citrulline wasn’t so 
i still have around a kg lying around but the thought of taking makes my stomach revolt
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