My lean body mass has increased by 3% just from reading Agetron posts. I admit that my rapamycin use is a confounding factor in my N equals one.
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I’m curious and look out for rapamycin and ceramide interactions too. But in the meanwhile, this is out, on using myriocin for ceramide inhibition on aged mice: https://scitechdaily.com/researchers-identify-a-new-hallmark-of-aging/
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Zazim : My lean body mass has increased by 3% just from reading Agetron posts.
Hahaha… what helped??? Curious.
Was in the gym today with a Marine buddy… beast of a guy… 240 pounds 6ft. 4 in.
I told him his mass is enviable.
His reply was … trade it for your shredded look.
So there it is.
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Osmosis!
Reaching 20 characters
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Channeling health and fitness your way fellow guinea pig. 
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Thanks for sharing, great data. Do you work out on days taking Rapa ?
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No, not typically (though I haven’t detected any differences when I do).
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I monitor all of these things closely. No change in resting heart rate since starting rapamycin and no change in resting heart rate on the day I take rapamycin and the day following. Similar results for HRV. No change.
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Some report anecdotally that they feel strong and can have vigorous workouts when they hit the gym after having taken rapamycin. Others report anecdotally they feel weak in the gym the days/the week after taking rapamycin.
There is mTOR independent protein synthesis that is not inhibited by rapamycin. Citrulline is one substance that,might be beneficial for muscle building when in mTOR inhibited state. Why? One can speculate that it is due to increased muscular perfusion and subsequent oxygen utilization? This might also be the mechanism by Viagra that keeps the brain younger and less prone to alzheimers. According to this “logic” it might be a good idea to use citrulline before going to the gym after taken rapamycin.
In vitro:
http://aups.org.au/Proceedings/44/13P/13P.pdf
“In conclusion, L-citrulline preserves rates of protein synthesis and protects myotubes from wasting in a different manner than L-arginine. We demonstrate a novel direct protective effect of L-citrulline on protein metabolism and skeletal muscle cell size that is not mediated by signaling through the mechanistic Target of Rapamycin. Instead, we show these effects are mediated through the inducible NOS (iNOS) isoform. This is the first study to describe a nutritional modulator of iNOS mRNA expression by skeletal muscle cells and could have important implications for the treatment of muscle wasting conditions.
“L-CIT may improve exercise capacity by upregulating muscular perfusion and subsequent oxygen utilization.” “In addition, the action of L-CIT on muscle function also is related to its ability to promote muscle protein synthesis. “ “Future research is still needed to decipher the contribution of endothelial versus neuronal NO production to the vascular and muscular benefits observed after L-CIT supplementation”
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How does this result correspond with your rapamycin protocol?
I felt that dosages of 8mg+ were negatively affecting my performance so switched to a more conservative 5mg/week in December. As you can see, I am now performing at close to my best all time level despite only doing 6 hours per week.
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Dose is important… higher doses for me were not great… 6mg plus GFJ.
Now doing 2mg and GFJ. Will have new testing done in a few weeks.
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I’m 56, male, and I take 5 mg Rapa once a week on Monday and do workouts on my Tonal from Monday - Friday. My protein intake is highest at breakfast and dinner and at 150 lbs, I try for 1.6 mg/kg of protein daily. I also take exogenous testosterone (I have hypogonadism) and am experimenting with peptides.
I see consistent gains in strength and lean muscle mass with regularity and have a body fat content of 14%. I don’t do Metformin at all. I honestly feel my best the 2 days following Rapa dosing, but can’t say I ever feel fatigued by the weekend. I follow my stats pretty closely and other than my cholesterol going up the only thing my doc noticed is that my kidney function has improved, to the point where he was surprised at the results. The nice thing about the Tonal is it tracks all of your output, strength gains, reps and charts the improvements for me, so I know the gains are real. Between that and the biometric scale I truly believe that Rapa has done nothing to inhibit my gains.
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My workouts, virtual cycling are intense, and pretty sure my max heart rate has gone up since Rapamycin. Getting even healthier.
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I just wish l-citrulline wasn’t so 
i still have around a kg lying around but the thought of taking makes my stomach revolt
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No. Just the opposite. You will find Nih reports and others showing rapamycin protects aging muscle thru Akt dependent short term activation of mTor1c but Akt Independent chronic activation of mTor1c appears to be detrimental to cells. At least in mice. Rapamycin directly stimulates muscle strength.
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Following up on last year’s sprint triathlon, I did another triathlon recently. I did a similar timing of dosage, 10 weeks on rapamycin and then 8 weeks off. The big difference was last year I was on a compounded version of rapamycin, This past year I have been on either Biocon or Zydus at levels of 3-8 mg weekly taken with fats. My presumption is that I have much higher blood levels of rapamycin this past year versus the compounded pharmacy capsule version without enteric coating.
This year’s triathlon was a bit longer and in a different location. So rather than compare times, I will use results placement to compare events.
Last year I had exceptional gains in my training and triathlon results. Placing 65th of 180 m/f finishers
This years results as follows:
Placed 89th of 153 m/f finishers - a lot worse than last year’s result, but more to the mean as to how I typically do in a sprint triathlon. I had trained well (but raced poorly-swim in particular). But as a broad measure I wanted to see if my rapamycin usage could be seen as a performance enhancing substance.
Last year:
Resting heart rate went down in a linear fashion during training from 50 bpm to 42 bpm
This year:
Resting heart rate gains were less and more erratic. Measuring anywhere from 55 to 45 to 50. Definitely some gains in endurance but not the dramatic gains from last year as far as bpm
Last year:
Excellent sleep 8+
This year:
Sleep 6-7 hours. It got to the point where I was considering using a dose of rapamycin to enhance my sleep. Some irony as I used to complain about rapamycin messing with my sleep. Over time this has changed to an sleep enhancement. My sleep wasn’t bad, but not what is needing to excel at a higher training level.
Annual Physical: Had my annual physical before the event. Normal blood measures, with the exception of free testosterone levels above normal range. Not taking trt and only have last year’s blood test to measure against. And that was somewhat high also.
Conclusions: At a higher dose of rapamycin and taking a break during training, I did not see anything suggesting it helped or detracted from my training and placing in the triathlon. As far as the year before, maybe it did at lower dosage.
Future dosing: I plan on taking smaller doses of rapamycin. 2-3mg Zydus every 10 days or so in the coming year. I will also consider 1mg a day for a week/then off rapamycin for 7 days. I will use subjective measures of sleep, energy levels, etc to gauge how to dose. If I do the triathlon in 2024, I will use a low dose regiment during training and see how it goes.
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I’ve used 6 mg rapa for 4 Mo’s now and I exercise 6 days weekly. I’m making nice progress in strength and size but I also wonder if it inhibits my muscle protein synthesis beyond the age related anabolic resistance at 72.
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