A possible combination or something to stay away?
I would not take them at the same time as Curcumin enhances the metabolism of rapamycin.
https://www.nature.com/articles/srep06587
(the above is everolimus, but I think the same applies for sirolimus (rapamycin))
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Curcumin’s metabolites activates CYP3A4. But Curcumin also have a (weak) inhibitory effect on mTOR and shows potential in anticancer research. So in theory it should not be taken together with Rapamycin.
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I asked the Perplexity AI what the half life of curcumin was and got this answer.
When administered orally:
- The absorption half-life is around 0.31 hours
- The elimination half-life is approximately 1.7 hours in rats, though these values are often below detection limits in humans1
I asked just figure out what the “conflict window” might be.
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