Copy and paste the link above if you receive a blank page.
The drug is raperymicin.
The reference they give is;
² Yatscoff RW, Boeckx R, Holt DW, Kahan BD, LeGatt DF, Sehgal S, et al. Consensus guidelines for therapeutic drug monitoring of rapamycin: report of the consensus panel. Ther Drug Monit 1995;17:676-80.
The reference paper says “In whole blood, ~95% of RAPA is sequestered within erythrocytes.” That’s potentially a very different statement from the quote from the first paper, as RAPA is probably distributed widely in other sites than blood.
Whole blood, serum, and various plasmas are not interchangeable sample matrices. While some analytes may give similar results, equivalence can only be ensured by testing matched samples. Whole blood contains RBCs that may occupy as much as 60% of the volume. Some analytes, such as Parathyroid Hormone (PTH), partition freely between the red blood cells and the plasma so that whole blood and plasma values are the same within experimental accuracy. Others, such as lipoproteins, are strongly influenced by red blood cell content. Still others, such as some immunosuppressant drugs like cyclosporin, partition between RBCs and plasma in a temperature-dependent manner that reflects the temperature history of the sample. To avoid this problem, whole blood is the preferred sample for measuring immunosuppressant drugs.