I upped my Rapa dose from 2mg per week (I’m erring on the side of caution) to 4mg. Earlier this week I felt as though I had the beginnings of a canker sore. I’m celiac and used to get them quite frequently until my diagnosis and I cut out wheat and gluten. Thankfully, it went away within a day. On Saturday I woke up with what looked like 3 insect bit marks on my neck and face. I took my Rapamycin dose on Sunday and yesterday one of the marks was pretty angry and swollen. I can’t say for certain if it is the Rapamycin, but it is quite unusual for me. I am a bit surprised as it’s a low dose. Having a dental procedure next week, wondering if I should skip my dose …just in case.
Out of an abundance of caution, I always skip a dose if i have any wounds or procedures.
The “insect bite marks” might be acne, as I have seen some people report… Rapamycin and Acne
Thanks, that’s incredibly helpful and interesting. I’ve never experience any kind of acne before, which is why I assumed it was the Rapa. I’ll keep an eye on it. My dental procedure is the middle of next week, so I’ll skip my next dose. I guess on the plus side, it shows that it’s having an effect.
I got the same. Pimples/acne on my neck since starting rapamycin. No canker sores at all which I’m happy for as I increased my dose really quickly. I take 6-8mg weekly.
Pimples don’t hurt. Just annoying if anything. They also heal very slowly.
Same, never had acne and now having a huge pimple om my neck.I´m taking 6mg with fat and Metformin.
Same as you, I didn’t got canker sores, but I got acne every time, it’s a common side effect of rapamycin.
Some papers report that young male are more prone to develop acne after taking rapamycin, I am in late 20s, same as you, and I am oily skin, I regularly apply retin-a (tretinoin 0.1% on nose, tretinoin 0.25% on face) to prevent acne developed.
Unlike the usual acne, the acne induced by rapamycin are really painful and very huge, it usually takes 2 weeks or more long to fade, and if the pimples bust, the wounds heal very slowly(approximately 2-3 time longer than usual)
I have tried topical tretinoin, topical steroid, topical antibiotics, oral antibiotics, but they all seem not very effective to rapamycin induced acne, I am still experimenting the way to treat those annoy acne effectively, If anyone have successfully treat acne, please share your experience to us, thanks guys.
Unlike the usual acne, the acne induced by rapamycin are really painful and very huge, it usually takes 2 weeks or more long to fade, and if the pimples bust, the wounds heal very slowly(approximately 2-3 time longer than usual)
Exactly what I’m going through right now! And the “normal” acne that I get on my face heals at a much quicker speed than the rapamycin induced neck acne which is still on my neck like 4-5 weeks later, it has faded and heal up a lot but not completely gone. So strange how the different acnes heal at different speeds, I got a pimple on my forehead last week, fully gone within 8 days but the neck acne from 4-5 weeks is still visible. so so strange!
I’ll be trying some treatment creams for the neck acne caused by rapamycin ill keep you updated if they work. Right now I feel like the acne on my neck is going to take a really long time to heal.
Has anybody ever tried L Lysine for the canker sores or pimples? Just an idea. I don’t take such a big dose that I get them yet, but my wife swears by the L Lysine for mouth sores.
Just out of curiosity. Has anyone come across any articles about interactions between Rapa and Finasteride? I take low dose finasteride for hair loss. I found a site that mentioned that Finasteride increases Rapa blood serum levels. I was a little surprised that I have symptoms already on what I’m guessing is quite a low dose.
I take the rapamune pfizer brand which I believe is the brand name and I get mine from my local chemist in Australia (not online). But you’re definitely right. The people buying online from India might be potentially getting some binders/fillers so it would be nice knowing where they source their rapamycin.
LeeJohn, Use hydrocortisone cream for rapamycin rash.
I’ve tried low potent Hydrocortisone cream, but it didn’t wok well.
I don’t know if it’s safe to change to high potent Clobetasol Propionate, because subcutaneous infection is also a common side effect of rapamycin, Clobetasol may complicate infections (if there were infections).
LeeJohn, I see your point. Hydrocortisone cream works for me, though inconvenient, and I’ll likely have to continue using it daily while taking Rapamycin. I’m not concerned about bad long-term effects using hydrocortisone, but Clobetasol Propionate long term would concern me. The infection possibility Clobestasol … I have no thoughts on this. Good luck. I hope you find a solution.
Hi Paul, I would be a bit concerned about a possible Staph infection-a complication of Rapamycin. If it is a Staph you should take an antibiotic eg Azithromycin
Thanks, I hadn’t considered that. It’s cleared up, but it looks as though I have another spot forming. Weird.
Yes I tried it and it worked! I had a large sore lump in my lower lip after taking my weekly dose and within a couple of hours of taking the lysine the soreness had gone and by morning the lump was gone.