Rapa & monoclonal b-cell leukocytosis

I asked Grok to evaluate what in my pharma stack was possibly linked to the MBL I’ve developed in the past year or so. The highest probability was for rapamycin. I did a search on MBL on this site and found nothing. Am I really the only rare bird on this site wondering about this?

My physician tells me my MBL is something we should just observe for now, but it could progress to CLL, which is also mostly a wait-and-see diagnosis. Still, in the long term this doesn’t seem compatible with my longevity goals.

Anyone have any experience, observations, or research to share on this topic? Thanks!

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FWIW: At age 85, my absolute lymphocytes have been on the high end for many years. As my other routine blood tests are all normal, my primary physician, who is a gerontology specialist, doesn’t seem concerned about it. I don’t know what my B-cell status is.

“Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic condition characterized by an abnormal population of identical B-cells in the blood. MBL is not cancer, but it is considered a precursor to B-cell cancers like chronic lymphocytic leukemia (CLL). For many, MBL remains stable throughout their lives and never requires treatment.”

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