According to the authors "paradoxically, in 6/12 subjects we observed a rebound effect on phospho-p70s6k where phorsphorylated protein levels exceeded baseline at later time points (including 28 days later)
Unfortunately, they don’t state explicitly what dose resulted in the rebound, but they do add that “we determined rebound was driven by the concentration of sirolimus”
What do you all make of this?
6/12 with rebound; with 3/12 with levels above baseline at 28 days?
I realize these are small numbers and it is difficult to draw conclusions.
As an aside, did anyone notice that Cmax for the GF baseline 15 mg was greater than the Cmax for the GF baseline 20 mg (prior GF intervention); I wonder if this is due to patient variability or small sample size.
