Hi…sorry it has taken me so long to respond. Your question addresses one of the many things about rapamycin that have not been adequately tested in humans. I regularly combine intermittent fasting with rapamycin. IN Blagosklonny’s 2019 article titled Fasting and rapamycin: diabetes versus benevolent glucose intolerance…he states " asting and rapamycin: diabetes versus benevolent glucose intolerance."
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4x a year I fast for 96 hours, just electrolytes and water intake. I found an interesting report that adequate intake of spermidine may be required to achieve highest levels of autophagy under those conditions.