AIUI the mechanism for this is via inhibiting JAK/STAT
IMO this is about reducing the effect of IL-10 and therefore increasing NF kappa B, thereby increasing the level of the citrate/tricarboxylate transport protein and as a consequence increasing acetyl-CoA levels in the nucleus.
People normally have between 50 and 150 micromolar citrate in their blood serum. Hence to increase this takes quite a bit of citrate (it is also metabolised quite quickly).
Also you need to be careful not to take too much as acid.
Personally I would avoid Janus Kinase inhibition as it interferes with a significant pathway and the side effects of serious interference could be material.
On Janus Kinase inhibition not being without the possibility of negative consequences. If possible please? (I could Google search but would be helpful to know what has convinced you)
There are other Jak inhibitors and there is plenty of material around (see link below). However, I personally am concerned about impacting on the NF kappa B pathway. It has its role when it needs to be increased and/or reduced.