According to this Japanese News Report, senescent cells (and attending inflammation) are necessary in addition to high cholesterol to cause cardiac events and arterial plaque.
Is this why Rapamycin may cause benign lipid dysfunction? It prevents senescent cells from forming as a senomorphic and helps clear them out so that arterial plaque can’t form even in the presence of high LDL cholesterol.
Senescence is IMO caused in the main by differentiation problems. Although mitochondrial efficiency is part of this the shortage of acetyl-CoA as a result of IL-10 effects is perhaps the most important driver in the long term.
I thought it was the plaque buildup itself which caused inflammation in the endothelial cell lining? Maybe I have misunderstood. However, it’s the inflammation which is targeted by low dose Colchicine which is why the FDA recently approved it to be used immediately after certain CV events.
If Arterial Plaque is in part caused by epithelial cells not differentiating properly and becoming senescent (which I personally think is part of the cause as well as Lipid issues) then reducing senescence should remove arterial placque. The main issue with this might be how quickly this happens.
What has not really been clarified is what causes senescence. I think a lot of it is failed differentiation of stem cells.
Senescent endothelial cells and vascular smooth muscle cells are found in atherosclerotic plaque, and studies indicate that these cells are involved in progression of plaque.
Mummies reveal that clogged arteries plagued the ancient world
Scans suggest that there’s more to heart disease than a modern diet.
Clogged arteries are seen as the quintessential symptom of an unhealthy modern lifestyle. But the condition was common across the ancient world, even among active hunter–gatherers with no access to junk food, a study of mummies has found.
“There’s a belief that if we go back in time, everything’s going to be OK,” says cardiologist Greg Thomas of the University of California, Irvine, a senior member of the study team. “But these mummies still have coronary artery disease.” The paper is published in the current issue of The Lancet1.
For heart disease, you need a relatively high level of lipids plus inflammation. If the inflammation causing arteriosclerosis is caused by senescent cells, then a two pronged approach to fighting heart disease is warranted.
Reduce LDL and ApoB
Reduce senescent cells
The best way to do #2 is through senomorphics such as Rapamycin and Taurine.
Senolytics are effective as well, but not as effective as senomorphics that prevent senescence in the first place.
Came across a new paper on citrate transporters and I thought of your comments.
This article is much too technical for me and I don’t pretend to understand it. But, it is open source and complete.
“The citrate transporters SLC13A5 and SLC25A1
elicit different metabolic responses and phenotypes
in the mouse”
I’ve been doing D&Q for a few months. Feel fantastic (used to get headaches the day after - I’m on once a fortnight as per ITP protocol) now the only way to describe it (and this might be psychosomatic) is cleaned out. Like I’ve flushed my body of all the senescenct filth
Stress is an underrated killer. Without even looking up any literature on the subject, I can tell you some of the things that I have observed.
It kills sleep
It causes depression
It raises blood pressure
It causes stress eating in many people. Stress eating is caused by people using food they like for comfort. This I have seen so many times at work, but seldom see this issue addressed.
Yeah, nothing better when the most random problem pops out of nowhere than to eat a large plate of unhealthy food, or other similar behavior…
It’s not suprising people are ‘unhealthy’ with how everything seems like it’s falling apart. It’s important to keep perspective and not stress over the small stuff (relative to other possible or actual bigger stuff, it’s small).
Just a stroll through the forest doesn’t sound too bad, we do that nowadays for recreation. But the parasitic infections, plague, violence, and infant mortality would suck.