Attia does low dose CT scan, to my knowledge. I think the radiation isn’t something to worry about, in the context of life in general
I would have to assume so, but I think it would be super difficult to prove with a trial. But in general, people who are sedentary get more cancer, people who are active get less, and now we have like the joining part, where people with cancer have better outcomes with exercise. So IMO it’s likely that exercise ticks box boxes.
What I’d be really interested in is knowing the dose and type of exercise. For example, I wonder if resistance training would qualify under the 4 hours per week.
And FWIW, I find it really hard to believe there’s any sort of “one size fits all” general statement for cancer. I’m sure lactate and mitochondria are important, but you get foetuses with cancerous growths in the womb, or really young kids tragically getting fatal cancers. It’s hard to imagine they have metabolic health or mitochondrial problems, and if they did, how that wouldn’t have been determined already.
That’s like the trial that could be powered to detect any effect in cancer prevention. But if prospective cohort studies show a reduction in cancer as well, I’d act as if it is causal until further evidence. It’s like cholesterol lowering meds only being powered to detect effects in people with high risk of CVD. We still believe it will be the case in those with low risk over time. But we have genetic studies as well, I don’t know if that could be established for exercise → cancer. Maybe future studies can find a biomarker that exercise improves and which explains the reduction in cancer, which there’s genetic variation in that exposure. Then it’d be easy to see if it’s causal and even have an important biomarker to track. Pharma would probably find a way to drug it as well.
Yes, but you’d need an enormous population. These people already had cancer, and there’s a very high percentage of reoccurrence. If you grabbed random people from the general population, the general chance of cancer within the trial period is pretty low.
As for exercise biomarkers, you might be interested in this: https://www.motrpac.org They’ve published a ton of papers now, omics (transcriptomic, proteomic, kinome, metabolome etc) datasets etc showing acute responses to exercise.