Glancing at the thread the argument appears to be about the statement
“You can see that if you survive past 5y you’re very likely to make it to year 10”.
Where 50% survive to 5 years and 60% to 10. Hence 83% of those alive at 5 years survive to 10. I would think 83% is fairly described as very likely.
It’s never good when people’s credentials go to their head. Appreciate your contributions @adssx
@adssx, good info.
The all cancers combined chart might misleading though. You could have the deadly cancers, like pulmonary, drive most of the downward slope in early years; and then past year 4 or 5, you’re left with the “curable” cancers, like prostate or breast cancer. To me, this doesn’t demonstrate survival to year 5 is an indicator of survival to year 10. I’m not arguing that p5 is not a good measure; on the contrary, it seems to be an excellent one; it’s just that chart may not be a good way to show that it is.
Seeing this by cancer type, like the laryngeal chart is more convincing. That chart is very encouraging too, much progress made already.
Yes we need to check cancer by cancer but I assume in most if not all cases 10ySurvival > 5ySurvival^2. And ChatGPT seems to agree on that even for the most aggressive cancers: ChatGPT - Cancer Survival Rates Comparison (I didn’t double check the answer)
As previously posted: https://acsjournals.onlinelibrary.wiley.com/doi/full/10.3322/caac.21858
I had a chuckle at EBV infection being called “modifiable” - 90-95% of adults are infected.
Very interesting report. If accurate, about 37% of the proportion of attributable cancer causes can be eliminated by eliminating cigarette smoking, excess bodyweight, alcohol and UV radiation, interventions that are relatively easy to accomplish.
The report attributes pretty low percentages of risk to low fruit and vegetable, processed meat, red meat, low fiber, whereas specialists seem to attribute higher qualitative risk proportions to such factors.
Luckily, it is reported to contribute to only 0.2%. If the figure is accurate.
KarlT, for user’s that hide their profile information, go to your own profile/preferences/users. You will find a way to suppress user posts by adding their name and selecting normal, muted or ignored.
Doesn’t appear to work for moderators
I asked ChatGPT with reason and search (o3-mini) about this with good evidence and it suggested a couple of preventative strategies:
Breast cancer: tamoxifen, raloxifene
Prostate cancer: finasteride, dutasteride
Lung cancer: smoking cessation
Colorectal cancer: aspirin
Liver cancer: hepatitis B vaccine or antivirals with chronic infection.
Seems legit, prompting matters a lot. I used Claude 3.5 to help create the prompt.
My daughter has been looking at these glucans and whether it is a reasonable strategy, both for cancer and infectious disease:
I’m in over my head. Does anybody have thoughts? Seems like for somebody that doesn’t have cancer it would cause inflammation?
Apparently the beta glucans generally have anti inflammatory effects, even as they can enhance immune function, but of course it’s complicated. Dr. Oracle seems to have a reasonable summary:
Question: Does beta glucan increase inflammation?
Beta glucan, a polysaccharide found in various sources, has been the subject of numerous studies investigating its effects on inflammation in the body. The relationship between beta glucan and inflammation is complex and context-dependent.
Beta glucan has demonstrated the ability to reduce pro-inflammatory cytokines in several studies:
While beta glucan can reduce certain inflammatory markers, it also has immunomodulatory effects that may enhance immune function:
Beta glucan consumption influences gut hormones, which in turn can affect immune responses:
The effects of beta glucan on inflammation may vary depending on:
While most studies indicate anti-inflammatory effects, it’s important to note that:
The evidence suggests that beta glucan generally does not increase inflammation in the body. In fact, it often demonstrates anti-inflammatory properties. However, its effects are complex and can vary based on the specific context, source, and individual factors. Further research is needed to fully elucidate the relationship between beta glucan and inflammation in various health conditions and populations.
[Answer generated by www.DrOracle.ai]
Sources for the above AI search (unfortunately I can’t get rid of those two icons partially blocking the final reference):
Thanks for doing this, it helps quite a bit. Hard to believe it actually works. I still have reading to do.
Removal of fallopian tubes almost completely eliminates women’s chance of ovarian cancer.
Researchers at University of California Los Angeles (UCLA) found that stress-related neurotransmitters and obesity-related hormones activated CREB (cyclic AMP response element-binding protein), which was shown to promote the growth of cancer cells in the pancreas.
In the study, mice that ate a high-fat diet were more likely to develop precancerous lesions. When stress levels were also raised through social isolation, the lesions grew even more.
The stress-related cancer risk was more pronounced in female mice.
Based on these findings, the researchers suggested exploring the use of existing medications to reduce the risk of obesity- and stress-related cancers.
More information: Xiaoying Sun et al, Stress and Obesity Signaling Converge on CREB Phosphorylation to Promote Pancreatic Cancer, Molecular Cancer Research (2024). DOI: 10.1158/1541-7786.MCR-24-0785
I asked Deepseek for a concise explanation with scientific articles on the immunomodulatory effect of Reishi mushrooms. That’s maybe the most effective medicinal mushroom (for prevention) if you must choose a single one.
Reishi mushrooms (Ganoderma lucidum) exhibit immunomodulatory effects through bioactive compounds like polysaccharides (e.g., β-glucans) and triterpenes. These components regulate immune responses by:
Enhancing Immune Activity:
Suppressing Overactive Immunity:
Balancing Response:
Reishi modulates Th1/Th2 balance, promoting appropriate immune reactions depending on physiological needs [5].
References:
(For full access, consult the cited journals or books.)
