What do you call “healthy” and “disease” here? I mean: from which levels of ApoB (or whatever other marker) do you consider someone to have a “disease” and not being “healthy”?
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I mean the actual clinical recommendations for the use of medications.The comment was made on a general level, not specifically directed at Ezetimibe. I use it myself, but on the other hand, I have a known elevated genetic risk for cardiovascular diseases.
I use few medications for which there are no clinical indications, but I have often thought about what I wrote.
Yes, I think they are referring to colon cancer. Fortunately, it’s easy enough to screen for.
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Full story:
New generation of cancer-preventing vaccines could wipe out tumors before they form
Shots enter early clinical trials for healthy people at high risk for disease
When Dave Dubin learned at age 29 that he had colon cancer, it wasn’t a big surprise. His grandfather and father had both survived the disease. “It was almost the Dubin way, and we just went on,” Dubin says. He had surgery and chemotherapy, but his cancer came back 10 years later. Genetic testing finally found an explanation for his family’s trials: a mutation in a DNA repair gene that lets genetic errors pile up in dividing cells. The disease, Lynch syndrome, comes with up to a 70% lifetime risk of cancer.
Dubin, 55, gets annual colonoscopies, endoscopies, and imaging scans, which caught a third cancer, in his kidney. His eldest son, Zach Dubin, 26, inherited the DNA repair mutation and also regularly gets checked for cancer. “It’s no fun. Nobody enjoys it,” Dave Dubin says—not the 2-day colonoscopy prep and procedure, nor the worrying about possible tumors. The disease also turned him into an activist. He and his family in Haworth, New Jersey, launched a nonprofit, AliveAndKickn, to promote research and awareness of Lynch syndrome, which affects an estimated 1.1 million people in the United States.
…
Vaccines to prevent certain types of cancer already exist. They target viruses: hepatitis B virus, which can trigger liver cancer, and human papillomavirus, which causes cervical and some other cancers. But most cancers are not caused by viruses. The Lynch vaccine trial will be one of the first clinical tests of a vaccine to prevent nonviral cancers.
The idea is to deliver into the body bits of proteins, or antigens, from cancer cells to stimulate the immune system to attack any incipient tumors. The concept isn’t new, and it has faced skepticism.
https://www.science.org/content/article/new-generation-cancer-preventing-vaccines-wipe-tumors-form
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21 posts were merged into an existing topic: The HPV Vaccine Reduces Risk of Cancer for All, not just Women, New Data Show
Alas, I’m seeing disappointingly small effect sizes, where the HRs are statistically significant (90% of cancer types).
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Yes, nothing is clinically significant. But at least it shows that omega 3 supplementation is probably safe from a cancer point of view.
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I find this interesting as I know people who have had a stroke and then get diagnosed with cancer a few years later…
Epigenetic age and long-term cancer risk following a stroke
Background
The association between increased cancer risk following a cerebrovascular event (CVE) has been previously reported. We hypothesize that biological age (B-age) acceleration is involved in this association. Our study aims to examine B-age as a novel contributing factor to cancer development post-CVE.
Conclusions
Our findings suggest that epigenetic accelerated aging, as indicated by Hannum’s EEAA, may play a significant role in the increased cancer risk observed in CVE survivors.
Cumulative incidence of cancer in the cohort. Values represent the number of patients at risk and the cumulative number of events. A shows the cumulative incidence function in the whole sample, while in B we stratified the incidence by tertile-split Hannum extrinsic epigenetic age acceleration. Time is represented in years. T1, first tertile; T2, second tertile; T3, third tertile
Open Access Paper:
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Yet another reason to split my ezetimibe pills in half?
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Is it a good journal? The first thing I think about if they got a significant result simply by random chance (after all if you test for 30 cancers, one will be significant to such a degree), but they should’ve corrected for this.
I think the essence of this is that both strokes and cancer are diseases of aging.
I would argue that both result in part from a reduction in mitochondrial efficiency.
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No it’s a low quality paper as I noted when I posted it.
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Called the Acid King by the media,[3][4] Stanley was the first known private individual to manufacture mass quantities of LSD.[5][6][7] By his own account, between 1965 and 1967, Stanley produced at least 500 grams of LSD, amounting to a little more than five million doses.[8]
Owsley is in the The Sunshine Makers (2015) documentary I think and which explains all of this for those who weren’t from that era or even consumed (maybe @Steve_Combi was a part of it).
I took a small dose of LSD when I was 20, I think I found that good.
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It’s a good reason for me to stop it! Was taking half pill for a few months. Noticed occasional nausea in the morning after I take it. Done with ezetimibe!
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Dozens of studies prove the benefits of ezetimibe. The cancer risk comes from a single paper by a traditional Chinese medicine research group (
). Until proven otherwise, the risk/benefit ratio seems clear and massive in favor of ezetimibe.
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I wouldn’t base your ezetimibe decisions on one Chinese paper. There’s a good chance (50%+) it’s fake.
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We’ve identified many direct links between poor diet choices and digestive cancers," explains nutrition epidemiologist Yohannes Melaku.
“Unhealthy dietary patterns, marked by high consumption of red and processed meats, fast foods, refined grains, alcohol and sugary beverages, present a worrying relationship with an increased risk of gastrointestinal cancers.”
Responsible for 1 in 3 cancer deaths worldwide, gastrointestinal (GI) cancers can occur virtually anywhere in the digestive system, from the throat to the stomach, pancreas, intestines, rectum, and anus.
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One in five new colorectal cancer patients in the United States is under 55, according to a Wall Street Journal analysis of data from the National Cancer Institute. That is nearly twice the rate in 1995. A recent meta-analysis led by the American Cancer Society found that 17 of the 34 most common cancers — including those of the small intestine, pancreas, and kidney — are occurring more frequently in younger people. Some of them had previously been declining but are now on the upswing again.
Here’s the really scary part: While death rates for colorectal cancer patients over 65 are dropping, they are increasing among younger patients. Scientists say these early cancers can be more deadly because they are often not caught until it’s too late for treatment. (Colonoscopies are not recommended until age 45.)
As a millennial prone to health anxiety, I have the same question: Why is this happening to my generation? Unfortunately, the short answer is: We do not know for certain. But let’s dig into the long answer.
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