Please do note that there are reasons to think things might actually go in the other direction
So might be something to look into before one tries to increase BMR
See eg
High Basal Metabolic Rate Is a Risk Factor for Mortality: The Baltimore Longitudinal Study of Aging
And
“IDEAL” Aging Is Associated with Lower Resting Metabolic Rate: The Baltimore Longitudinal Study of Aging
https://agsjournals.onlinelibrary.wiley.com/doi/abs/10.1111/jgs.12740?utm_source=chatgpt.com
This was a timely share for me.
My sister just went to a periodontist to discuss pinhole and grafting procedures to fix her receding gums.
My dentist feels as long as I brush really well, it’s no big deal to have them, but having said that, I’m younger and only have a handful that are starting to recede
Has anyone researched this and is this something that is important to address for long term mouth health?
I have used Lactobacillus reuteri for Oral Health. But not recently. It improved my gums but no need for it now, when I am on rapamycin.
I think it is an important diseases of aging issue. A few years ago I lost a tooth and my dental hygienists thought I was on the way to lose another. However, I have sorted the issue through our normal techniques and am now OK.
Association…
Empagliflozin + nasal insulin for dementia prevention:
Another SGLT2i win: Antidiabetic agents and dementia risk in type 2 diabetes: A systematic review and network meta-analysis 2025
Analyses of treatment rankings further revealed the relative effect on reducing dementia risk in the following order: SGLT2i > GLP1-RA > TZD > DPP4i; insulin ranked the lowest.
The most effective antidiabetic agent in reducing dementia risk in T2DM is SGLT2i, followed by GLP1-RA, TZD and DPP4i, whereas insulin is associated with an elevated risk of dementia.
Important to specify that higher insulin in the peripheral nervous system (PNS) is associated with AD, but increasing insulin in the central nervous system (CNS), aka the brain may be protective against Alzheimers.
I would so appreciate if it anyone has a clue to how to get the “newly validated device” for intranasal insulin that Craft references. I think the name of the manufacturer is Aptar. I have been using little spray bottles, like the bottles that flonase comes in.
Labcorp plans to offer Roche’s recently FDA-cleared blood test to assess early signs of Alzheimer’s disease and other causes of cognitive decline for patients 55 years and older.
The blood test, which is minimally invasive and designed for use in primary care settings, garnered the go-ahead from the FDA in mid-October. The Elecsys pTau181 test was developed in collaboration with Eli Lilly and can help rule out Alzheimer’s-related amyloid pathology.
Currently, about 7.2 million people in the U.S. have Alzheimer’s, and that number is expected to double by 2050, Labcorp said in an Oct. 23 press release. The company will start rolling out the test nationwide early next year.
Will the test cost an arm and a leg, or only an arm?
It seems to be not only important but underrated. That UK dentist Ellie Phillips that @Joseph_Lavelle interviewed a while back does not seem to be a nutter. On the interview she was a bit sprawling with her answers but a few things she said that were kind of off topic actually clued me in to the possibility of her being much brighter than she seemed. So after binging on more content I am open to trying her system and have ordered the parts — waiting for them to make their way to my house piecemeal through Amazon. No major problems for myself yet but I want to preempt them and I want to set my kids up for success. I’m not pleased with their dental hygiene habits. I will say I brush religiously and have since I can remember, but almost never floss (can probably count on both hands the number of times I have, in total, in almost 40 years alive) and my teeth are in good shape, so are my gums. Flossing always felt wrong and if I haven’t suffered for neglecting it, she’s already validated and explained something no dentist can account for.
My improvement on her system which called for having an am and a pm toothbrush to ensure proper drying has been to order a wall mounted multi brush holder with built-in drying and UV sterilization. Even before she said anything about this it always struck me as wrong the way toothbrushes spend their time between their excursions into our mouths. They can collect dust and pathogens or flies can land on them for all we know during the day. I want them in a secure and sanitary place. And yes I notice how mold or mildew can grow on anything that stays even slightly tacky around the clock. So they need to dry out properly in between brushing sessions.
I listened to that podcast and ordered that fantastic toothbrush! My poor poor neglected sonicare. And now I have an am/pm toothbrush, too!
You will feel seen…… I have always kept my toothbrush in a medicine cabinet, and when they recently had to remove the door to send it off for repair, I immediately put my toothbrush in my drawer. I said what if a fly lands on it!!!
I have a flossing stick and I use it quite few times before changing the disposable head. Someone told me that’s gross. I said you use the same toothbrush for months at a time, and the flossing head can be cleaned much easier!
Fun fact: When I’m in a hotel, I put my toothbrush away before housekeeping comes. (And truly, I don’t even have my room cleaned, but that is a long story).