MR studies are lifelong, so the absolute risk should be pretty high. Of course it depends how long you have the exposure and what the lifetime prevalence is.
If you believe the MR data (without controlling for the FADS gene cluster), then DHA increases aortic valve stenosis controlling for LDL-c/apoB, as well as other clinically relevant increases in depression rates, lung cancer, and colorectal cancer.
1.36 (95% CI 1.10–1.68) for aortic valve stenosis (Fig. 2). None of these results, except for aortic valve stenosis, passed our multiple testing correction threshold (P < 0.006).
Hoth Therapeutics Announces Positive Pre Clinical Data HT-ALZ Shows Promising Breakthrough in Alzheimer’s Disease Research Acute treatment with HT-ALZ led to a rapid (~15%) reduction in brain interstitial fluid Aβ levels, within 20 hours
More good news for those of us working to keep our APOB / LDL-C as low as reasonably possible. Statins, for most people at least, are probably your friend.
People with low levels of low-density lipoprotein cholesterol (LDL-C) in their blood have a lower overall risk of dementia, and a reduced risk of Alzheimer’s disease specifically, according to research published in the Journal of Neurology Neurosurgery & Psychiatry.
Taking statins also provided an “additional protective effect” against the condition for those people with low levels of bad cholesterol, researchers found.
The Paper: (Open access)
Low-density lipoprotein cholesterol levels and risk of incident dementia: a distributed network analysis using common data models
Results The LDL-C levels below 70 mg/dL (1.8 mmol/L) were associated with a 26% reduction in the risk of all-cause dementia and a 28% reduction in the risk of ADRD, compared with levels above 130 mg/dL (3.4 mmol/L). For LDL-C levels below 55 mg/dL (1.4 mmol/L), there was an 18% risk reduction for both outcomes. Among those with LDL-C <70 mg/dL (<1.8 mmol/L), statin use was associated with a 13% reduction in all-cause dementia risk and a 12% decrease in ADRD risk compared with non-users.
Conclusion Low LDL-C levels (<70 mg/dL (<1.8 mmol/L)) are significantly associated with a reduced risk of dementia, including ADRD, with statin therapy providing additional protective effects. These findings support the necessity of targeted lipid management as a preventive strategy against dementia, indicating the importance of personalised treatment approaches.
A group of volunteers aged 45 to 65 years old received one of two doses of suvorexant or a placebo pill, an hour after researchers tapped their cerebrospinal fluid to collect a small sample.
It’s a paper from 2023. Sciencealert always republishes old stuff to get clicks. As they note at the end of these republished articles: “An earlier version of this article was published in April 2023.”
“current research shows that DHA mainly crosses the blood–brain barrier in the form of NE-DHA or LPC-DHA.
LPC-DHA in plasma can be converted from PC-DHA catalyzed by phosphatidylcholine-cholesterol acyltransferase. Choline is, in turn, a synthetic precursor of PC
Several studies have shown that single supplementation with fish oil (DHA dietary supplements) does not significantly enrich DHA in the brain [13,14,15] because DHA is released in the form of free DHA or monoacylglycerol during TAG digestion and exists in plasma as TAG, which is not well absorbed by the brain”
Apoe4 probably doesnt get through the whole cycle as well, so direct lpc supplementation is less risky ?
This nutrient, plasmologens, has a broad benefit but posting here on the brain/alzhemers thread given high value for such use:
I watch everything by Alex Kikel. Search youtube on Alex Kikel. He’s got alot of peptide, mitocontrial, anti-aging helps. If I got seriously sick I’d pay what ever his consulting fee is, hes that good. Not limited by a license and the AMA. See his interview with Jay, Hunter on the latest products they are bringing to market. Search for the most recent Q&A. See biolongevitylabs.com and new products like BioMind. I take the sub components and these products are expensive but still cheaper then buying the ingredients separately.
There’s no alternative besides very high end foods for plasmologens then https://prodrome.com
We buy frozen fish roe and eat an oz every AM. We take many of the freeze dried organ pills, liver etc, 2 raw eggs with my pint of bone broth mix every AM. We buy low PUFA eggs, no corn or soy… Plasmologens in many nutrient dense food. But prodrome at least is a measured dose of these plasmologens. I’m on a subscription to save a few…
Sorry, I don’t remember. I was never very convinced of the benefits of copious supplementation with fishoil, so I wasn’t that motivated to pay attention to brands. I do take 500mg EPA only three times a week, but that’s it.
Cardiorespiratory fitness and cardiometabolic health are associated with distinct cognitive domains in cognitively healthy older adults.
Background: Aging is associated with progressive cognitive decline, as well as increased prevalence of cardiometabolic risk factors and reduced cardiorespiratory fitness. In fact, reduced cardiometabolic health and cardiorespiratory fitness are both associated with a decline in cognitive functioning. This study examines the common and distinct contributions of these cardiovascular health factors on cognitive variability across different domains in cognitively healthy older adults.
I bought some of this LPC supplement so I hope it work. It seems like its most surefire way to get some into the brain, and maybe the only way in some studies. But I did find this study that showed maybe even LPC-DHA does not get into brain, only the EPA. Is anyone able to download the full study? https://www.plefa.com/article/S0952-3278(24)00055-3/abstract
