I think it is an important diseases of aging issue. A few years ago I lost a tooth and my dental hygienists thought I was on the way to lose another. However, I have sorted the issue through our normal techniques and am now OK.
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Association…
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Empagliflozin + nasal insulin for dementia prevention:
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Another SGLT2i win: Antidiabetic agents and dementia risk in type 2 diabetes: A systematic review and network meta-analysis 2025
Analyses of treatment rankings further revealed the relative effect on reducing dementia risk in the following order: SGLT2i > GLP1-RA > TZD > DPP4i; insulin ranked the lowest.
The most effective antidiabetic agent in reducing dementia risk in T2DM is SGLT2i, followed by GLP1-RA, TZD and DPP4i, whereas insulin is associated with an elevated risk of dementia.
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Important to specify that higher insulin in the peripheral nervous system (PNS) is associated with AD, but increasing insulin in the central nervous system (CNS), aka the brain may be protective against Alzheimers.
I would so appreciate if it anyone has a clue to how to get the “newly validated device” for intranasal insulin that Craft references. I think the name of the manufacturer is Aptar. I have been using little spray bottles, like the bottles that flonase comes in.
Labcorp signs on to carry Roche’s newly FDA-cleared Alzheimer’s blood test
Labcorp plans to offer Roche’s recently FDA-cleared blood test to assess early signs of Alzheimer’s disease and other causes of cognitive decline for patients 55 years and older.
The blood test, which is minimally invasive and designed for use in primary care settings, garnered the go-ahead from the FDA in mid-October. The Elecsys pTau181 test was developed in collaboration with Eli Lilly and can help rule out Alzheimer’s-related amyloid pathology.
Currently, about 7.2 million people in the U.S. have Alzheimer’s, and that number is expected to double by 2050, Labcorp said in an Oct. 23 press release. The company will start rolling out the test nationwide early next year.
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Will the test cost an arm and a leg, or only an arm?
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It seems to be not only important but underrated. That UK dentist Ellie Phillips that @Joseph_Lavelle interviewed a while back does not seem to be a nutter. On the interview she was a bit sprawling with her answers but a few things she said that were kind of off topic actually clued me in to the possibility of her being much brighter than she seemed. So after binging on more content I am open to trying her system and have ordered the parts — waiting for them to make their way to my house piecemeal through Amazon. No major problems for myself yet but I want to preempt them and I want to set my kids up for success. I’m not pleased with their dental hygiene habits. I will say I brush religiously and have since I can remember, but almost never floss (can probably count on both hands the number of times I have, in total, in almost 40 years alive) and my teeth are in good shape, so are my gums. Flossing always felt wrong and if I haven’t suffered for neglecting it, she’s already validated and explained something no dentist can account for.
My improvement on her system which called for having an am and a pm toothbrush to ensure proper drying has been to order a wall mounted multi brush holder with built-in drying and UV sterilization. Even before she said anything about this it always struck me as wrong the way toothbrushes spend their time between their excursions into our mouths. They can collect dust and pathogens or flies can land on them for all we know during the day. I want them in a secure and sanitary place. And yes I notice how mold or mildew can grow on anything that stays even slightly tacky around the clock. So they need to dry out properly in between brushing sessions.
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I listened to that podcast and ordered that fantastic toothbrush! My poor poor neglected sonicare. And now I have an am/pm toothbrush, too!
You will feel seen…… I have always kept my toothbrush in a medicine cabinet, and when they recently had to remove the door to send it off for repair, I immediately put my toothbrush in my drawer. I said what if a fly lands on it!!!
I have a flossing stick and I use it quite few times before changing the disposable head. Someone told me that’s gross. I said you use the same toothbrush for months at a time, and the flossing head can be cleaned much easier!
Fun fact: When I’m in a hotel, I put my toothbrush away before housekeeping comes. (And truly, I don’t even have my room cleaned, but that is a long story).
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Haha I hear you about the flies. And I too have been tempted to keep mine safe in a drawer but then I’m afraid it will rot in there for want of ventilation and sunlight. That’s why I bit the bullet on this system that will dry it, disinfect it with UV light, AND keep it away from flies looking for nests. It wasn’t expensive on AliExpress but hope it’s not a piece of junk.
But what about her total care system? Did you try it or only tried the toothbrush? With something like that, I either go all in or I don’t, to give it a fair chance. So I ordered the toothbrushes and the birch sticks and the xylitol gum and mints and loose powder to boot — along with the 3rd party products and double checked they each were the variant she vouched for. If I don’t notice amazing teeth it won’t be for lack of faithful adherence.
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Walking a Few Thousand Steps a Day May Reduce Alzheimer’s Risk
A new study suggests that exercise can be particularly beneficial for older people at a higher risk for the disease.
Walking a few thousand steps a day can slow cognitive decline in older adults who are at increased risk of developing Alzheimer’s disease, according to research published Monday. Getting about 3,000 to 5,000 daily steps was advantageous compared with doing less physical activity; the benefit peaked around 5,000 to 7,500 steps.
The link between exercise and dementia is well established, and many neurologists say physical activity is one of the best ways to reduce the odds of developing the condition. The new study, published in the journal Nature Medicine, sheds light on what might be playing out in the brain and who could benefit most from exercise.
“We’ve known for several decades that physical activity is associated with a reduced risk of developing dementia,” said Kirk Erickson, the chair of neuroscience at the AdventHealth Research Institute, who was not involved with the research. What the new study has done that is “really quite important and quite unique,” he said, is identify how exercise might be influencing some of the proteins implicated in Alzheimer’s disease.
The study followed nearly 300 older adults between the ages of 50 and 90 for an average of nine years. None of the participants had cognitive impairment at the start of the study, but about 30 percent had considerable buildup of the protein amyloid-beta in their brains.
Read the full story: Walking a Few Thousand Steps a Day May Reduce Alzheimer’s Risk (NYTimes)
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Thank you! I’ve been waiting for this! I wish everything was moving faster😢. There are so many I’m waiting on. People are suffering, deteriorating and waiting unnecessarily long while these old systems are moving at the pace of 1900’s medicine. A horse drawn carriage in a rocket age.
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Sorry to put a damper on this.
Liraglutide and dementia
The ELAD clinical trial (NCT01843075) investigated liraglutide in 204 mild Alzheimer’s dementia patients over 12 months but failed its primary FDG-PET endpoint of preserving brain glucose metabolism. While researchers reported 50% reduced brain atrophy and slower cognitive decline on secondary measures, leading experts deemed the effect sizes too small for meaningful clinical significance. Despite initial positive media coverage, specialists classified it as a negative study overall. Two Phase 3 trials of semaglutide in dementia are expected to conclude in 2026.
We will have to await some further trials to see how much it affects cognitive decline. Though I don’t see how the reported reduction in brain atrophy does not translate into a reduction of cognitive decline.
Meanwhile, of course, it does have many other benefits.
Also, FWIW: ChatGPT-5 opinion:
- There’s no strong reason to think liraglutide is uniquely capable of protecting the brain.
- There is good reason to think this might be at least partly a GLP-1 “class effect.”
- But we absolutely cannot assume that all GLP-1 / incretin drugs will give the same 50% reduction in brain atrophy until their own Alzheimer’s trials report.
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14313?utm_source=chatgpt.com
https://www.drugs.com/liraglutide.html
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