This systematic review with meta-analysis finds that low-frequency, short-duration high-intensity training interventions are likely to improve or at least delay the decline in global cognition in older adults with cognitive impairment or dementia.
Open Access Paper:
Based on this, I increased my omega 3 intake to 1.2g a day. Since I already take moderate doses of tmg, choline and b vitamins, this combination should hopefully protect my brain function.
Good news for acarbose and AD (in mice though…): Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer’s disease 2024
Interesting
The novel solution provides accurately simulated flavour samples (known as virtual flavour, developed in collaboration with New Food Innovation) via an easy-to-use low-cost dispenser, which could be used by a nurse as part of an annual health check, in pharmacies, care homes, community centres and even in the home.
While in the trial stages at the moment, academics hope that one day an inclusive mobile Alzheimer’s screening unit could reduce significant pressures on the NHS and ease waiting times for those who are struggling to get an appointment with their GPs.
Professor Alan Chalmers from WMG at the University of Warwick said, “In this simple screening test, people will be given different flavours to smell and taste – they then determine which is sweeter, less astringent, smells more of lemon, for example. It’s an easy, non-invasive test which can be rolled out to people quickly across the UK.
Along the same lines this was a fascinating story about the discovery of a smell test for Parkinson by a hyperosmic spouse.
A drug with no toxicity that might prevent and treat dementia in ApoE4 carriers. Very interesting indeed.
Recommended viewing by Dr. DaySpring:
Yes, an excellent presentation on The Proof podcast. I knew about the ApoE connection to dementia but this illuminated how this apolipoprotein ties in with ApoB and ApoA1 and also the relationship between brain cholesterol and peripheral cholesterol. Tom Dayspring was at his best and it was a lively discussion. Fascinating subject.
Greater MIND diet adherence was associated with decreased risk of cognitive impairment in female participants.
Typically, individuals with early-stage Alzheimer’s disease perform progressively worse on standard neuropsychological tests, losing a few points every year. But in Chan’s study, participants’ test scores have remained stable. Brain volumes have shown no signs of shrinking and levels of a disease-associated protein in the blood have even trended downwards. “These patients have conquered the test of time,” says Chan, who presented the findings at an international conference on neurodegenerative diseases
https://www.nature.com/articles/d41586-024-03147-1
More discussion on the topic:
