Wait, no carbs??!!
Not exactly ketogenic, but carbs (other than what came from low glycemic vegetables) were verboten.
SUPER healthy whole food diet.
Actually, the dietary guidelines easily allowed for a keto derivative.
The only difference from my strict ketogenic diet is my higher intake of MUFA/PUFA plant fat, and my likely lower animal protein intake to hit 70% fat/25% protein macros.
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Emphasize âpilot,â as in small (intervention n=22, control n=22). I love the diet and lifestyle interventions since they mostly match mine. The results are promising, but wonky, as the control group aged significantly over the 8 weeks while the intervention grew younger.
I wonder how much younger you could be with a longer intervention?
Ha, the very definition of confirmation bias.
Alternative title: âA wide selection of variables has a non significant effect on an unproven age calculatorâ
Small sample, short duration, not individual level control for diet/exercise confounders.
Re carbohydrates, the only comments:
âThe diet restricted carbohydrates and included mild intermittent fasting, both designed to lower glycemic cycling. Avoid added sugar/candy, dairy, grains, legumes/beans. Exclude white potatoes,
sweetcornâ
Clearly, the study designers had some intrinsic carbohydrate dietary/aging bias in mind, but why not any aging reference rationale? The fasting was simply overnight, 12 hrsâŚvery mild indeed.
2 years ago, I did a blood based DNA methylation test (Horvath licensee): https://www.mydnage.com/. Came back showing 3 yrs younger than my biological age.
My last Levine Phenotypic Age Calculator (An epigenetic biomarker of aging for lifespan and healthspan | Aging) Feb '22 showed my Phenotypic age as 46, about 13 years younger than my biological age. (Sorry, more coffeeâŚ11 yrs younger!)
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Indeed. You can see how hard it is to do powered RCT trials with humans when you allow this many variables!