Potential Detrimental Interactions Between Metformin and Supplemental Dietary Fiber in Type 2 Diabetes

https://onlinelibrary.wiley.com/doi/full/10.1111/1753-0407.70101

Summary

  • Despite clear evidence that dietary fiber reduces development of diabetes and associated complications, many consume inadequate amounts.
  • Additional dietary fiber, provided to people with pre-diabetes and T2DM and habitual low fiber intake, improved BMI and LDL cholesterol.
  • However, a variable HbA1c response was observed: a reduction in those not taking Metformin and an increase in the small group using metformin alone.
  • The interaction between metformin and supplemental fiber needs to be clarified and, in the meantime, used together with caution.
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I find this quite interesting, but I start from a probably quite rare position of having a weekly HbA1c for about 3 years. (a few weeks are missed).

I see lots of issues with the reliability of HbA1c measurements before you get into the technical aspects of measuring two different versions ketoamine with or without aldimine. Hence when you have people using single values and a variance of less than 2 mmol/mol I have difficulty reading anything into the outcome although when averaged over a large enough sample (and I don’t think their sample is large enough for this) it can give more reliable information.

I would also like to know how much psyllium fibre they used. Most supplement capsules are quite small and I would think to move the needle properly would take more than 10g of fibre containing substances. I am a fan of chia seeds for this purpose.

“how much psyllium fibre they used.”

Similar to my thinking, I would also stress “supplemental fibre”, and not worry about fibre intake. Needing supplement fibre, in my opinion, indicates a messed up diet, probably eating too much, period. Else, fibre in food is not a problem, no matter the fibre intake volume. They need to redo this study with simply diverse high fibre foods, not those supplements.