As it is known, the c38 enzyme is known as NADase, that is, it breaks down NAD + in cells and reduces its level. CD38 is mostly present on T lymphocytes. A hypothesis came to my mind. Now, we always do not want rapamycin to reduce the number of T lymphocytes and see this as a side effect. But if it reduces the number of T lymphocytes, couldn’t it also indirectly reduce the CD38 level and thus indirectly contribute to the NAD+ level?
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