KEY POINTS
Meh. Only difference with Rybelsus is bigger dose.
Exactly. Bigger dose with more side effects and the same food restrictions. I suspect this will be a bust and quickly outclassed by orforglipron which can be taken any time of day with or without food.
The generics are coming…
I have been experimenting with gray orforglipron for about a month now and it has been really amazing. As someone who is spooked by gray injectables it has been a really nice option. And in theory, once it becomes more popular, should be a lot easier to produce with cheaper prices.
That’s interesting…so far, reviews of gray market orforglipron have been pretty mixed at best. It could be that some sources are better than others. In a big Time Magazine interview last year, Eli Lilly says the molecule is difficult to manufacture, so I wonder if that’s the issue. There might also be additives to the Eli Lilly pill that allow for better dissolution/absorption.
I’ve been sticking to a lower dose, 4-5mg a day, that could also be part of me avoiding the GI symptoms I’ve seen a lot of people mention.
I don’t think it’s quite as light-switch magical as the weekly glp1s but I think there’s a place for it.
I’ve seen more people flat-out say it doesn’t seem to work, or that it wears out way before the 24 hour period. But reviews are not from a GLP1 native population, which probably makes a difference.
I wish Hims good luck, not on the silly threat of a lawsuit, but on getting the formula right for the pills.
I’m looking to do the worlds first worm lifespan study on Orforglipron. I’ve contacted Ora Biomedical about it. Once I hear back I’ll make a post to give more information to people here.
I’m really excited about this drug.
Wow, feels like Hims is playing with fire here. It’s hard to argue that the Wegovy pill is in shortage or that they are truly compounding custom tablets.
This is definitely in violation of regulations but they’re making the calculation that the current admin would rather see inexpensive availability than enforce the rules.
Will be very interesting to watch.
Violation is in the eyes of the beholder, as different jurisdictions define personalized prescriptions differently. A personalized prescription can be a tablet of a different mg, or with different coating, or different fillers, etc . Some jurisdictions have concluded that the simple fact that a prescription was written is personalization.
I agree that this sounds like a cash grab for suckers.
Fwiw the wegovy pill really is a semaglutide pill like rybelsus. It’s semaglutide + snac that transports the wegovy through the GI tract.
They’re having a meltdown now.
Using the pejorative Big Pharma as a company like this is pathetic.
