From a JAMA journal and the Framingham dataset so pretty high quality. The results are not too surprising, basically, physical activity in midlife (45-65) and late life (65+), decreases risk of dementia. Early life (<44 yrs) physical activity does not, however.
Question: When during the adult life course is physical activity most associated with risk of incident dementia?
Findings: In this cohort study of 1526 early adult–life, 1943 midlife, and 855 late-life participants in the Framingham Heart Study, individuals with the highest levels of physical activity at midlife and late life had 41% and 45% lower risk of all-cause dementia, respectively, compared with those with the lowest levels of physical activity, a statistically significant difference. Early adult–life physical activity was not associated with dementia risk.
Meaning: These findings suggest that timing efforts to promote physical activity during midlife or late life may be warranted to help delay or prevent dementia.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2841638
Time to get off the couch, I guess…