"Pharmacokinetics of long-term low-dose oral rapamycin in four healthy middle-aged companion dogs"

As I do not see a place to post links to published papers

This paper, may give you an overview and ideas, titled;

“Pharmacokinetics of long-term low-dose oral rapamycin in four healthy middle-aged companion dogs”

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Compared to that pharmacokinetic study, Matt Kaeberlein’s group is using a higher dose in the rapamycin arm of the Dog Aging Project (0.15 mg/kg once weekly).

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It was the same research group - just an earlier, preliminary study I think: