It makes me wonder if a alternating schedule on a twice weekly dosing regimen could mitigate the potential for problems. My thought was 50 mg twice a week for Doxy, but I don’t know minocycline well enough to know the dosing. Also, how hard is it to get minocycline? It’s not likely the traditional medical system would be willing to prescribe it. I wonder if it’s available from international sources? I see that it’s cheaper through a veterinary sources by a factor of 10!
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Minocycline is commonly prescribed in the US, I write scripts for teens with bad acne who get stomach upset with doxycycline. It has neuroprotective features and decreases inflammation in the central nervous system. Super inexpensive especially if you use Amazon medical and pharmacy.
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Just be careful with long term use of minocycline because unlike doxy, mino can cause a permanent blue/gray discoloration of the teeth and gums. It can also cause dark navy-blue patches in the skin. I’ve seen this a number of times over the years, usually patients who come to derm in a panic and have been on minocycline for years, prescribed by a provider who didn’t know any better. This is almost never seen with short term use but gets more common the longer it is taken.
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I have taken it BID for years, and acne, still at 64, but I believe you, just have not experienced it pesonally.
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Wow you are fortunate. At least you’ll know what it is immediately if it ever happens. It can be reversible after cessation of minocycline in some cases, but not always.
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Here’s an update on Peter’s protocol. Posting this impartially. I’m a really interesting using Immuna from Immunis and the Throne Immune reprogramming.
Definitely something I’d like to get my hands on.
PROTOCOL AS FOLLOWS:
- PEMF (Pulsed Electromagnetic Field) therapy runs automatically from 5:00-5:30am while I’m still in bed; and then again at 9:30pm when I’m going to sleep.
Morning Routine (5:30am - 7:00am)
- Red Light Therapy (30 min): I use three devices simultaneously: a PlatinumLED BIOMAX 900 panel for my body (20 minutes), a laser cap for hair growth (10 minutes), and a red-light mouthpiece for gum and teeth health (10 minutes). David and I both swear by red light: it reduces inflammation and promotes healthy skin and tissue repair.
- Meditation: 15 minutes using an Ohm device. My meditation focus every morning is on GRATITUDE and Optimism. The data is clear: optimists live 15% longer than pessimists. Your mindset is the most underrated longevity lever.
- Workout: 40 minutes of weight training, targeting upper and lower body. Muscle mass is one of the strongest predictors of longevity. My goal: resistance training 5 days a week, 1g protein per pound of bodyweight, and 5g of creatine daily.
Morning Peptides
- CJC-1295: 5 days/week, a growth hormone-releasing hormone analog for tissue repair and recovery.
- SS-31 (Elamipretide): Sunday & Wednesday. Targets and repairs mitochondria directly.
- MOTC: Sunday, Wednesday, Friday. a mitochondria-derived peptide that enhances metabolic function.
- Tirzepatide (microdose): Sunday only. It’s a next-gen GLP-1 receptor agonist. David and I discussed this at the Abundance Summit. Beyond weight loss, GLP-1s are showing remarkable benefits for the heart and brain. We’re both watching this space closely.
Evening Peptides
- Sermorelin: 5 days/week. A peptide used to stimulate the pituitary gland to produce and release more growth hormone.
- BPC-157: Sunday thru Thursday. A peptide used to accelerate healing of tendons, ligaments, muscles, and gut tissue.
- DSIP (Delta Sleep-Inducing Peptide): A naturally occurring neuropeptide that, when administered intranasally, is reported to promote slow-wave (deep) sleep and improve sleep quality.
My Supplement Stack
As I’ve mentioned before, I take a stack of over 60 supplements per day divided into a wake-up, AM, Lunchtime, PM and Bedtime pill packs. Without listing everything, I want to say I mirror nearly 100% of what David listed above.
As always, I have to say you should discuss your supplements and meds with you physician . Having said that, the following supplements are, in my humble opinion, useful for most everyone, and a few I will list in addition to those listed by Dr. Sinclair:
- Creatine 5 grams every day: Fuels muscles, boosts strength and power output.
- Coq10 with PQQ: Cellular Energy and support: mitochondria support.
- Urolithin A: Mitochondria Support.
- N-Acetyl Cysteine: Precursor to glutathione (the body’s master antioxidant).
- Magnesium Glycinate & Magnesium Threonate: Brain and Sleep support.
Therapeutics
- Infrared Sauna: 3x per week, 20-30 minutes. I use a “Healing Sauna ,” which is super portable and keeps my head and arms free to do work. David and I agree: heat stress activates your body’s “adversity mode,” triggering longevity pathways. Your air-conditioned, comfortable life is actually working against you.
- Exosomes, Immuna and Throne Biosciences: Through Fountain Life , under the care of my physicians, I’ve used three different rejuvenation protocols, specifically: (i) IV exosomes (Kimera Labs ); (ii) Immuna, an experimental protocol under phase-2 FDA trial from Immunis ; and (iii) Stem Cell Educator Therapy by Throne Biosciences : a one-time, dialysis-like treatment that uses CB-SC stem cells derived from human umbilical cord blood to “re-educate” and reset the immune system.
My Skin Protocol. This Is Where the Science Gets Exciting
Here’s something I’ve become increasingly passionate about: your skin is not just cosmetic. It’s your body’s largest organ and a major driver of systemic aging.
Both morning and evening, I apply OneSkin’s OS-01 FACE and BODY formulations.
Why? Because the science behind OS-01 is some of the most rigorous I’ve seen in the longevity space. OneSkin was founded by four female PhDs from Brazil who asked a simple question: What if you could eliminate the senescent “zombie” cells in your skin that drive aging?
They screened roughly 1,000 peptide sequences and found one, OS-01, that does exactly that.
Here’s what the peer-reviewed data shows:
- Reduces senescent cell burden by up to 50% in skin tissue models.
- Decreases skin’s biological age by 2.5 years in just 5 days of treatment, measured by MolClock, the first skin-specific molecular clock.
- Increases epidermal thickness and supports collagen biosynthesis the key building block of younger skin.
- A new 2025 pilot study published in the Journal of Cosmetic Dermatology found that OS-01 BODY, their body moisturizer with the OS-01 PeptideTM, increased skin’s barrier strength , leading to a reduced systemic inflammatory marker (IL-8), even though the peptide never enters the bloodstream.
That’s not skincare, that’s longevity science applied through your body’s largest organ.
And this actually makes a lot of sense when you consider that skin is your body’s first line of defense against external aggressors, and the fact that we live in a toxic soup these days.
David’s work has taught us that senescent cells are among the primary accelerators of aging. His lab uses gene therapies to target them systemically. OneSkin is doing something complementary: targeting senescent cell accumulation in the skin with a topical peptide, and the downstream effects on systemic health are remarkable.
I apply OS-01 FACE morning and evening, and OS-01 BODY every morning. It’s part of my protocol because the science warrants it.
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The rapamycin plus doxycycline combo is interesting. I had not realized that both drugs are mtor inhibitors and autophagy promoters. This is an older paper from 2021. Rapamycin Plus Doxycycline Combination Affects Growth Arrest and Selective Autophagy-Dependent Cell Death in Breast Cancer Cells - PMC
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- Who you have to be to support this level of compliance? Billionaire? 5 times per day of supplement taking - only sorting this amount will take hours. And saunas, meditations, all other stuff… What is the purpose to prolong life if spending lifetime only on prolonging itself?
- What is the cost of all of it?
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For how long? Are you still on this regime? Have you any measurable benefits and adverse effects?
Because its pretty frequent use of dasatinib, not a usual drug, so your experience is very interesting.
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I was posting Peter Diamandis’s current protocol. It’s not mine.
FWIW…
Peter Diamandis’s has any and all re$ource$ required.
Cost is not a thought/issue to individuals with unlimited re$ource$.
What works is the only thing they want/look for.
I’ve already read about who is Peter Diamandis. No more questions)
But his experience is worthless for (almost) all of us. Just hope that such people move progress a little bit further.
I do not think so.
As some of us follow/try his dosing.
Most items are not very expensive, shopping around.
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Looks like he dedicated all his time to support his body. It’s a full time job with no weekends. It probably consumes all his energy. Wondering if he has any other interests in his life - probably no room for anything else.
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Not a fan of hi btw lol. Yeah, I might do some things he does (since some interventions are common knowledge already), but he isn’t someone I’m interested in following.
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Peter’s Investment & Advisory Portfolio
Abra, Alysm Energy, Anduril, Applied AI, Axonic, Booster, Cellularity, Colossal, E-Space, Form Bio, Fountain Life, Gameto, GhostFire, Haut AI, Human Longevity Inc, Immunis, Intelligent Internet, Invisible Technologies, Jetson, Life Biosciences, Lifeforce, Lila, Marvel Biome, Merge Labs, Newlimit, OneSkin, Openwater, Paradromics, PeroNova, REACT Neuro, Radicle Science, Science, SourceReady, SpaceX, Variant 3D, Vatomic, Viome, xAI, WHOOP, Retro Biosciences.
He has unlimited re$ource$.
When he speaks I listen.
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Amazing. Just curious but is this guy really giving himself 6 injections a day (peptides)? He is tougher (and braver) than he looks. I like the physical interventions: PEMF, red light, sauna, weight lifting are all useful. I’d add some cardio and HIIT. At his age I doubt he’s lifting hard for 40 minutes x 5 days a week so he could definitely shift some resistance training time to other systems. But all those supplements….? I limit myself to 10 supplements to avoid the slippery slope of wishful thinking.
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What this tells you is that taking lots of supplements like he does isn’t bad for you. If he doesn’t make it past 95, then I’ll reconsider my thesis.
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Funny. My thesis is people (me too, previously) take a lot of supplements to make themselves feel better about the lifestyle improvements they can’t live with. But maybe I’m missing out. I’ve decided I’d rather die of not taking something I didn’t understand than die from taking something I didn’t understand. Good luck to us all.
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I have a similar take. It’s his access that makes him interesting. He’s incredibly longevity focused and is invested in the bleeding edge of longevity science and the things he’s doing now are things that will undoubtedly end up being widely available in the next ten years. While 90 percent of what he’s doing it out of most people’s means it’s well worth tracking the compnanies.
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