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then asked whether DR longevity critically requires peroxisome function, specifically peroxisome protein import, using PRX-5 TPD. Animals on DR lived significantly longer as expected. However, we saw a complete abrogation of DR longevity in animals with induced PRX-5 degradation, showing that functional peroxisomes are a central requirement for DR longevity (
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This adds to the case for fenofibrate beyond the hypothesis: AI Analyzes Millions of Molecular Profiles to Uncover Overlooked Aging Interventions
fenofibrate → fenofibric acid → PPAR-α agonism