Peptides / Bioregulators

#554

Ok, so basically, I can dilute any 10mg peptide (most well-known ones) with one 1ml for example and it will be fine? The reason why I’m still keeping the question open is because a week or so ago I read somewhere a chart of dilution for most peptides and some of them had different ratio suggestions, for example let say BPC157 was 10mg to 1ml while CHK CU had it say 10mg to 2ml (unfortunately can’t find that chart now, but I know for a fact that there were different ratio recommendations for some). That’s why I was wondering if there is a specific reason other than what @Davin8r suggested is for practical reasons only.

Thanks for dosing explanation but that part I think is the easiest to figure out and believe it or not it’s the most explained all over the web, and I’m like who the hell do these people think they are dealing with :joy:. I thought all people in western world finish at least elementary school lol, but I understand how it can initially be a bit confusing especially when you dose in mcg or ug units.

Anyway, if anyone has anything specific about the dilution, please chime in but please keep away from how to come up with dosing portions. Thanks,

#555

Sleepdoc, do you mind describing some of the effects?

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#556

@Davin8r has the right answer. I usually don’t do less than 2mL per vial (but sometimes 1, sometimes 3) to get dosing accuracy and to avoid wastage when trying to get the last few drops out. Though you can always inject a little more solution in at the end.

Here’s Tailor Made’s peptide catalog. Scroll to the dosing charts section in the back showing all the different concentrations they use. It confirms what @Davin8r said.

For semaglutide and tirzepatide, you can also look at the pharma concentrations.

25835966 (1).pdf (2.4 MB)

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#557

Thanks @Davin8r and @AgentSmith. My question has been answered.
WOW the catalog is exactly what I (didn’t know) was looking for. Thanks again @AgentSmith

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#558

Hey Steve,
I’ve had chrondomaclia in my knees for almost 40 years. I would like to do more impact to assist my osteoporosis, but I have limits on what I can do pain free. Would one of these things help something that is not acute/new?

I do perfectly just fine day to day, so I have no interest is doing anything that could cause harm, but thought I’d throw this out there?

#559

I tried both - found Semax very effective and Adamax not at all. Just on my second test of Semax with similar results to the first time. Unfortunately, whilst my brain seems to be functioning like that of a 20 year old, my muscles aren’t responding in a similar fashion and I’ve managed to get fairly painful inflamed rotator cuffs with over exercising. I’m taking it easier this time around.

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#560

I have not seem much in the studies I’ve read with respect to osteo and chondromalacia and BPC + TB. Understanding the root cause and addressing that would be the first thing to consider and that is way beyond my education level :slight_smile:

They are not “pain releivers” per se as the pain relief comes from the injury being healed.

BPC has a benefit for soft tissue, ligaments and tendons. TB-500 similar benefits through a different pathway.

Here is some info on peptides that may help in is area.

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#561

Some peptides affect the pH of the final solution and “burn” when injected. Two solutions;

  1. use more diluent so there is less effect on the pH of the dose
  2. use Phosphate Buffered Saline solution

Some peptides “gell” if there is not enough diluent, one solution

  1. use more diluent
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#562

That’s a false statement
A minimal dilution is necessary to lower the risk of protein aggregates that lead to an immunogenicity effect, wich can be problematic long term. FDA require lab pharmaceuticals to study this phenomenon on their injectable protein-based drugs. Every change in concentration has to be studied again before approval

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#563

I wasn’t aware of this, but it makes sense if it applies to real-world medicinal peptides. That’s an even better reason to dilute more vs less, in addition to making syringe draws more accurate and decreasing gelling/burning of some peptides.

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#564

Great addition to the library.

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#565

What dose of Semax? How do you apply your amped-up brain?

#566

A third solution proposed by @Ulf is to inject GHK-cu–and maybe other peptides–into an upper quadrant of the glutes, I tried it and it works. No discomfort, no pain.

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#567

As my limited understanding of peptides in general is evolving from the deepness of the rabbit holes presented, I’m starting to look at some peptides like “vitamins”, not that they are vitamins but that we can use some of them in a similar manner.

For example as we age, we don’t process B6 from our dietary intake as when we were young. We have not become “desensitized” to B6, the system that processes it is impaired so we supplement B6.

Similar to reductions in our body’s ability to process (or make) a wide variety of the 7,000 peptides we produce to be healthy.

For example MOTS-c production declines as we age, we are not becoming desensitized, we are just making less. By “supplementing” MOTS-c we may be able to compensate for the reduced production as we age.

In my limited understanding, it appears that many of the bio-identical and some of the fragment type peptides available today may be seen/used the same as supplementing with dietary supplements.

Some peptides that have been created outside the human body, for specific therapeutic purposes, probably have long term and even short term issues outside their intended use.

Another example I’d refer to is HRT (hormone replacement therapy). When Test is used at a rational level, not much different than how a vitamin may be used, it is tremendously beneficial, and can be used for many years with no side effects. But when used at more extreme doses, it cause testicular atrophy and people will use other hormones/peptides to counter that. Similarly, vitamins at extreme doses can be toxic and harmful.

I don’t think we want to use the commonly available peptides as a “replacement” therapy, more like a supplement to help compensate for age related reductions in beneficial peptides.

This has guided my personal approach to peptide use, why I take certain peptides at specific times to mimic the hormonal circadian cycles.
IMG_7104

As this concept has started to evolve in my mind, I now look to understand the circadian cycle of any peptide that I use. My latest is with Thymosin Alpha-1 and I’ve found that it tracks the testosterone cycle. It has a 2hr half-life.

Basically;

  1. cycle/timing
  2. half-life
  3. contraindications
    Those 3 should lead to a rational dose

Took my first dose of 250mcg of TA-1 this morning.

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#568

Hi Jay, The first thing I noticed was better muscles. After about three weeks I noticed my biceps were bigger with the same amount of gym time. About an hour of weights a week. I figure this had to be a hormone effect since I hadn’t changed anything else. Great thing is I can still build muscle many months later so the bioregulators are still going strong. No habituation. Endurance also better. At 67 preventing sarcopenia is a main goal.
Other changes have been more subtle but still substantial. For myself and others I have seen improvements in sleep, body composition, vision, urinary frequency, balance, stamina, immune function, cognition, tinnitus, libido, skin, happiness, healing etc. One friend with a very pronounced tremor had perfect results. Overall it takes most people at least 2 months to notice changes.

Not trying to say these are the magic bullet, but they seem to be very useful for overall health optimization. I started them to lengthen my telomeres and was pleased with the other beneficial results.

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#569

I use some of the Bioregulators and peptides. I’m working on collecting the series of bioregulators to do the 60 day stacking protocol. I currently stack a GIP/GLP, and then also pin a BPC/TB/GHK-Cu daily, with some 2 or 3 week breaks every so often. I will be adding adding KPV - just want to decide if I will “add” it to what I am doing or use it to replace the BPC. I also do a daily immunity stack of TA1, Epithalon and Thymulin. This will continue through the winter and then I’ll take a break off of it in the spring. I just found out about the Rapamycin discourse forum from a member of the Peppys discourse forum I am in. I was quite excited to find this forum as I’m interested in Rapamycin and some of the other longevity peptides and other biologicals. I have a number of other peptides in my stash that I plan on utilizing.

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#570

Thanks for sharing this great catalog. A wealth of iinformation

#571

@Goodkitty - welcome to our Rapamycin forum and especially this Peptides and Bioregulators subforum that I started here. I am an avid Peppy member on your site and have learned a LOT from you and your members.
Looking forward to continued learning

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#572

Thank you so much. Now to make more time! (anyone have a peptide/bioregulator that makes more time in each day? - lol) The learning never ever stops! :books: :heart_eyes_cat:

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#573

I think meth gives you more waking hours LoL!

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