Not very informed about either, you are saying peptides are cheaper than bioregulators?
And do you mind sharing some you do and the cost/source? Thanks,
Have you ever come across somebody getting anhedonia from BP-157? Two members of this forum report this.having happened to them.
No, and I’d anticipate the opposite with this agent as it drives up BDNF. However, everyone is different.
Vera-Health.ai says the following on this topic:
BPC-157, a synthetic peptide derived from a protein in human gastric juice, has been studied for its potential therapeutic effects on various bodily systems, including the central nervous system (CNS). While specific research directly linking BPC-157 to the treatment of anhedonia—a symptom characterized by a reduced ability to experience pleasure—is limited, there are some theoretical connections based on its broader pharmacological actions.
BPC-157 has been shown to interact with serotonergic and dopaminergic systems 1. These neurotransmitter systems are crucial in regulating mood and emotional responses, and their dysfunction is often associated with anhedonia. By potentially modulating these pathways, BPC-157 might influence mood disorders, including symptoms like anhedonia.
Additionally, BPC-157 exhibits anxiolytic, anticonvulsive, and antidepressant effects, and it has been noted to counteract symptoms modeled after schizophrenia 2. These effects suggest that BPC-157 could impact various behavioral disturbances, potentially including anhedonia. Its ability to exert protective effects on the brain and peripheral tissues further supports its potential as a therapeutic agent for mood-related disorders.
Despite these promising aspects, it is important to emphasize that the evidence is primarily based on preclinical studies and animal models. Clinical studies specifically targeting anhedonia are necessary to confirm these potential benefits. The current understanding of BPC-157’s effects on mood and emotional responses is still evolving, and further research is essential to elucidate its mechanisms and efficacy in treating anhedonia specifically.
In summary, while BPC-157 shows potential in influencing neurotransmitter systems related to mood regulation, direct evidence supporting its use for anhedonia is limited. More clinical research is needed to establish its role in treating this condition.
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I had heart palpitations and tachycardia the first time I tried BPC-157. I thought maybe it was just a fluke since that reaction didn’t make sense to me, so I repeated at a half dose(50 or maybe 100 ug) a few days later and got the same reaction. I threw it away and will never touch the stuff again. Since then, I’ve also seen some other reports on Reddit from others who have had a similar reaction, but it still appears to be extremely rare given the popularity and wide use of this peptide.
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I buy peptides from China, which are the same, relabeled peptides available from domestic vendors, except they are much cheaper buying directly. I know of two sources for bioregulators, CosmicNootropics and Rupharma.com, but there are probably many more.
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Doctor Fraser do you think BPC 157 would help to heal my slightly torn meniscus?
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I can’t give individual advice (unless you have a visit with me) but in general it is something which either works or doesn’t. It’s not much money to use for 6 weeks at 250-500 mcg/day as common doses.
I believe @Steve_Combi can be contacted by message and has good quality sourcing for this.
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I’m far from an expert on an injury like you have, in fact zero expertise in that area at all so take the following with a grain of salt as it’s all anecdotal. As this is only my personal experience.
I’ve experienced benefits from BP-157 but… I use a combo of BPC-157 + TB-500.
I take 500mcg of each every morning, for over 14 months now. 3 months ago added a 3rd to that combo, MOTS-c
All my “old” injuries have responded. An old high ankle sprain that was a chronic pain point for over a year, gone. A back injury I suffered when I was 16 (52 years ago) that was intermittent over the years and would be triggered by a sneeze or reaching over my head, just weird innocuous triggers over most of my life, maybe once or twice a year. Gone.
My wife is on the same program.
When I do hard physical labour, I often think “I’m going to pay for that”, one nights sleep and I get up with zero effects. Our last big project was cutting down a tree in our yard. It was over 50’ tall and right next to my fence and house. I had to cut it down from as high up as I could get on a 15’ ladder, taking it down branch by LARGE branch. With my wife doing the lugging and me doing the cutting, it took over 4 hours of work. Both the house and the fence survived 
As a keyboard user, I had quite a few blisters LoL! Zero muscle pain the next day, just a bit tired. Joan had the same experience, no after effect from the work.
A friend has had 12 years of pain from 2 operations on her neck. A very athletic ball player who suffered significantly. She never stopped playing ball but did stop winter practise. Two months of the combo dose and she is astounded at being pain free for the first time in 12 years and back working out and doing winter ball practise that she could not do as she “saved” herself for the season so she would not be crippled up from winter practise.
I’ve got more anecdotes with friends and family on this one. A couple of them blow me away, as impressive to me as the example above.
I’m often asked why I take this every day and my answer is it helps keep me young or at the very least, feeling young LoL! It also gives me the confidence to do hard things “a person my age” might shy away from.
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FWIW:
I recently had a medical procedure that resulted in a large scar"
I had pre-planned and considered BPC-157, which has extensive anecdotal evidence and seems to be the preferred peptide for wound healing.
After looking over some peptide groups, I decided to try hexarelin.
“As a growth hormone secretagogue, hexarelin enables the body to use growth hormone to improve muscle, tendon, and bone repair following injury or intense exercise [9]. When the body is able to rapidly heal from tissue trauma, one can increase training intensity and/or volume without excessive fatigue or muscle damage.”
I have been taking hexarelin for three weeks, 100mcg three times a day.
My doctor was amazed by how rapidly the wound was healing. I noticed in the first week.
Considering that I am 83 and would not be expected to heal so rapidly is a testimony for hexarelin.
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GHK-u is also good for wound healing. And you may be interested Adamax, the new, souped-up version of Semax. Not cheap, but promises a “massive” boost in cognition. It’s comparable to being a zombie and chomping on the brains of neighborhood children. Could probably boost your IQ by 300 points.
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Me too. Except my combo is TB/BPC/GHK-cu. The results are unambiguous.
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Except that your response is ambiguous hahaa
More details please, dose, length you been taking, and specific benefits.
thanks,
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Primary complaints:
labral tear
extruded disk
osteo in the knee
bum shoulder
Peptides:
TB-500, 500 mcg EOD
BP-57 500 mcg EOD
GHK-cu, 500 mcg EOD
MOTS-c 100 mg twice yearly
SS-31 100 mg twice yearly
Physical therapy:
Mackenzie exercises
Dead hang
planks
isometrics
HIIT
Resuls:
No pain anywhere
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Safe to assume you aren’t taking 100mg of these all at once?
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No, 10 mg/day of SS-31 for ten days, followed by ten days of MOTS-c at 10 mg/day.
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MOTS-c has an ~4hr elimination life and is fully metabolized in a few hours. Regardless of dose. Yes a high dose will have a high peak and more area under the curve but the end point of full metabolization remains the same.
Since our body produces MOTS-c in response to physical “stress” and the amount of MOTS-c we produce declines as we age, I decided to add MOTS-c to my daily routine at a low dose of 250mcg per day.
I’ve had people say “what about de-sensitization, you need to cycle” and my response is… My body has been making this peptide (and 7,000 more) since before I was born and never became desensitized… What my body has done, is reduce the output of many things, including peptides like MOTS-c so my approach is to try and return certain peptide levels to what they were when I was younger… and never got desensitized
I believe influencers use that word to appear more “intelligent” I think, that for many peptides that are bio-identical or a fragment, it’s irrelevant. For anabolics, SARMs and a few non-human peptides it does apply.
Just my 0.02 from reading a lot of studies. Here is one overview that references a few studies
> Studies have shown that blood MOTS-c levels in young people are 11% and 21% higher than those in middle- and old-aged people, respectively
Another article with references
MOTS-c in relationship to a popular longevity drug Metformin
MOTS-c - Diabetes, and Aging-Related Diseases
https://e-dmj.org/journal/view.php?number=2725
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Do you happen to know any international reputable (someone has tested them for efficacy) source for peptides?
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Steve, how do you dose the Mots-c?
After reading the paper on diabetes, I think I will change my MOTS-c protocol from twice yearly to EOD for a month, which aligns with Dr. Seeds’ recommendations. He also suggests that MOTS-c can be cycled with other mitochondrial peptides, such as SS-31. So my protocol for MOTS-C would be 250 mcg EOD for a month, followed by 250 mcg of SS-31 EOD for a month. On the the other days, I will continue to squeeze in my TB-500/BPC-57/GHK-cu combination, also at 250 mcg of each.
The choice of 250 mcg is based more on economic than medical considerations. As you said elsewhere in this thread, I don’t have unlimited wealth.
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Review posting;
And
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