https://www.nature.com/articles/s41514-024-00160-6
A naturally occurring peptide called PEPITEM could potentially rejuvenate the immune response in older individuals and protect against ‘inflammageing’, which is widely believed to be the root cause of many age-related diseases.
Looks like an interesting peptide with a broad scope of benefits.
New therapeutic avenues in bone repair
Date: May 21, 2024
Source: University of Birmingham
Summary: Researchers have shown that a naturally occurring peptide (small protein) holds promise as a new therapeutic for osteoporosis and other disorders that feature bone loss, with distinct advantages over existing drugs.
Patent granted in 2017
Another recent Pepitem paper:
Whilst none of the pharmacophores or their peptidomimetics fully recapitulate PEPTIEM dual activity in vivo , enhanced bone formation and reduced resorption was observed in mice with ovariectomy induced osteoporosis in some macro and microscopic assessments. Collectively our data indicate that full-length PEPITEM or pharmacophores encompassing residues from both the N and C-terminus are required to achieve maximal pro-anabolic and anti-catabolic activity. The combination of the dual activity in a naturally occurring peptide with limited potential toxicological profile offers an exciting alternative approach to treating osteoporosis.”
https://www.sciencedirect.com/science/article/pii/S0753332225006833?via%3Dihub
I’d like to see more research on this as most of the current pharmacological treatments for osteoporosis have serious side effect risks