Hello, I am 3 months in the Generic Rapamycin (Sirolimus tablets) protocol with AgelessRx. I am a 49 year old retired physician in Florida. I have enjoyed browsing this forum and being a part of the Rapamycin community. Thanks
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Hello DrG,
I just started as well. I’m 6 weeks in, so far. Have you seen any changes in your health, body, or mental state? I’m 74 and trying to stay young. I also take NMN and Metfornim, but can’t say I detect anything much improved, at this point.
Sam K
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How are things going? When is the study going to end for you? When are the results coming out?
Hello Sam, I only noticed small changes when the dosage increased to 6mg weekly. Specifically a little weight loss and slightly darker hair. I also take Metformin. I occasionally use a CGM and didn’t notice any changes to glucose levels.
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Isnt the results here suposed to be done by end if desember ir has the trial changed?
Some of the guys from AgelessRx were at the Longevity Summit conference the other week. They told me that they were finishing up the trial (the last person is just finishing the process) but that the results will take a while to pull together and analyze… so they wouldn’t give me a date on when things would be finished and publicized… hopefully next year sometime. The issue is that the data right now is still blind (only the contracted pharmacy sending out the tablets knew whether a person was getting the placebo or the real thing), and the data , such as the biological age testing, Dexa scan info, etc. still resides with the collectors of that information so its going to take a while to pull it all together. And of course, the company doing it (AgelessRX) is a small startup company with limited resources… so they are working on it, but can’t move as quickly as we’d like.
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Looks like the Unblinding will start this week!
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I was in the 10mg arm of the Pearl trial. I am currently on 6mg/week with Ageless. I didn’t experience any notable changes, either positive or negative, through the trial. LDL cholesterol and triglycerides were elevated both before and after. I had a modest reduction in weight, although very little change in visceral fat. I haven’t received the Trudiagnostic results. My Phenoage went from -10.7 to -10.05. However, my Glycanage went from 34 to 47. I’m not really sure about the implications or relevance of that change.
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what about your energy level and something of an overall experience subjectively such as mental clarity, mood, etc?
May I ask how your sub-indexes changed, especially the three main indexes?
I am in this trial, month 2 still 2mg per week. Might be due to bmi? The tablets are brand name not compound. I also take LDN 4,5mg & my top ten supplements are within range of our general group consensus. Curious if other women further along are also only the tablets.
No real changes. I exercise almost daily and had, and continue to have, a lot of energy. My mental clarity and acuity were good and continue to be so. I am generally positive and optimistic (excessively so, according to my wife). If there were changes, they have been subtle.
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Youth went from .17/77th percentile to .172/32nd percentile
Shield went from .144/95th percentile to .187 99th percentile
Mature went from .29/17th percentile to .249/36th percentile
I was missing data from the baseline report for lifestyle and median. So, for the midpoint and endpoint –
Lifestyle .104/5th percentile to .1 /4th percentile
Median .386/9th percentile to .386/9th percentile
There was a clear change in the population data from the first test to the end point. For example, mature had a better absolute measure, but it was worse from a percentile perspective.
These samples were from 9/24/22 to 3/19/23.
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