PEARL / AgelessRX Rapamycin Trial Participant Feedback - So Far

We have a thread on the blood test here: How to get a Rapamycin (sirolimus) Blood Level Test

But we don’t recommend you do this to “unblind” yourself in the PEARL trial, because that defeats the goals of this blind trial…

We need more trials like this and want to support every one of them that gets funded so we all get better data on the use of this drug.

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Ola Tahoedenizen! Thank you for checking in my fellow PEARL study colleague. I am committed to being a good sport and NOT testing to see if I am on the placebo or the drug. Yes, lots of easy ways to determine that if I wished. What about you? Will you test?

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I also support the double-blind design. I could see doing this test if I had a concerning symptom or side-effect, and I or my doctor needed to know whether Rapamycin might be a cause or important contributor. But so far I haven’t experienced any apparent symptoms or side-effects. I suppose if I had a lip sore, I’d smile and react much as you have.

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Love it DeStrider! I am so sharing that.

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Is anyone on this blog currently enrolled in the AgelessRX Rapamycin trials? I was told it would be open to the public this Summer. Here’s a link to the invite only offering. Rapamycin Protocol | AgelessRx

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They told me they would only allow the 2 mg dose per week, in an email in response to my question. So, I won’t be pursuing this!

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Here’s what it says about the trial on Agelessrx website.
The generic (Sirolimus) protocol is a titrated plan to move from 2mg to 6mg per week over three months, ultimately ending at 6-8mg (at the discretion of the prescriber).

The compounded protocol is a titrated plan to move from 5mg to 10mg per week over three months, ultimately ending at 10-15mg (at the discretion of the prescriber).
So yes the Sirolimus protocol does start at 2mg but increases 6mg over a three months and then ending with 8mgs. My question is about the blood test they require every month. I presume I’d have to pay for that.

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They are running a “trial” and charging $150/month to be in it? I thought you usually get paid to participate, or at least it’s free!

That said, had I not already secured a source, I prob would have joined!

In the PEARL study they provide a ton of biological and blood testing that would cost you a lot more money than they are charging you - so its still a good deal!

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Good morning I am in the pearl study by ageless RX. Pretty sure I am not on the placebo. Started December 5,

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I paid $360 I think to join the study, everything else is include. If you are in the placebo group you receive the drug after the study. So far everybody has been very professional. Lots and lots of bloodwork a dexascan, Thorne microbiome test and another test I can’t remember the name. When I am done they will release all the data to me. Side effects a few mouth sores and weird skin spots nothing that worried me. I am 64 but I feel like I am Reentering menopause. Mood swings and spotting. I have had more energy and a few time the euphoria that is mentioned at night I feel very very warm.

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The ageless RX study that I am on you receive either placebo, 5mg, or 10 mg. For 48 months. $360 total. When done if you were on the placebo you get the real drug.They have another study when this one ends that will compare 10mg to 20mg…

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Ah, that does seem reasonable, even just for the data from the tests.

The link in prev post seems to indicate $150/month. I wonder if they got so much interest they realized they could charge more?

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Ageless is super stingy with my Acarbose prescription as well.

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I am in this trial. Started 10/22. It looks to me that Ageless RX is just selling Rapamysin for $150 per month. The free doc visit will decide on the dose to start with. My understanding.

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To clarify the PEARL trial. Not sure if I’m on placebo or the real thing.

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Hmmm my only cost $360 total, if on placebo you receive drug when done…

I started the trial 12/5/22

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