With Pasteurized Akkermansia, EGCG Green Tea for weight management, Chromium for balanced blood sugar, and Vitamin B2 for gut integrity.
Live vs Pasteurized Akkermansia MucT™
Live Akkermansia muciniphila is less stable and often destroyed by oxygen, stomach acid, and bile salts. Live bacteria can also interact with your diet and supplements, affecting your digestive system in unexpected ways.Pasteurized Akkermansia MucT™ is more stable, remaining functional in your small intestine and colon to strengthen your gut barrier safer and more effectively .
In 2004, the team of Professor Willem M. de Vos at Wageningen University discovered, described, and patented the application of the novel bacterium Akkermansia muciniphila MucT™ and its growth conditions for human use.
Dr. Muriel Derrien, a PhD student under de Vos’ guidance, successfully isolated and characterized Akkermansia muciniphila. It was the same team that named the strain in honor of Dr. Anton Akkermans, a famous microbial ecologist working in the lab.
This revolutionary strain helps to strengthen and support the gut barrier to protect against gastrointestinal, metabolic, and immune disorders including obesity, diabetes, and low-grade inflammation.
Akkermansia muciniphila is naturally occurring in your gut but can diminish with age and lifestyle changes. Professor De Vos and his team discovered an effective solution to replenish it, pioneering a breakthrough in the industry. After years of research, they engineered pasteurized Akkermansia MucT™, the strain’s most bio-efficacious and clinically studied form.
Pendulum’s Akk isn’t worth the price, although it’s live; each capsule contains only 100 million Akkermansia, while a capsule of pasteurized Akkermansia contains 30 billion."
Recent studies indicate that live Akkermansia can cause autoimmune kidney disease, and there are certain risks associated with long-term use.
Pendulum Akkermansia might not contain much but it certainly has an impact. When I first started on it I had loose bowels for 2 weeks. And then I had faster bowel transit times than pre Akkermansia. Then I tested my HbA1c and found it had fallen from 5.6 to 5.0.
The downside is I lost the benefit when I quit taking it but the benefit is big enough on my worst biomarker that I rank it above all the internet favorites: taurine, glycine, vit d, etc…none of which have ever done me any good that I can tell. I’m back on the Akkermansia train.
I’d conjecture that if one can reestablish meaningful levels of Akkermansia in the gut biome one could then maintain it by supplying the Akkermansia with the right set of prebiotics or whatever else on which it would “feed”.
Brian Greene writes about this. We’ve discussed this elsewhere on the forum.
Perhaps:
potato starch,
psyllium,
inulin,
apple skins,
Human Milk Oligosaccharides (HMOs)
HMOs, complex carbohydrates found in human breast milk, can promote Akkermansia growth - Greene recommends HMOs with apple skins (or powder).
Read this journal article, and you will find the reason。
Unexpectedly, we discovered that pasteurization of A. muciniphila enhanced its capacity to reduce fat mass development, insulin resistance and dyslipidemia in mice.
More importantly, the improvement of gut health by enhancing strengthen intestinal integrity and maintaining immune homeostasis was seen in both treatments; notably, pasteurized A. muciniphila had more effective. Similarly, treatment with the pasteurized form more effectively upregulated tight junction and regulated immune response-related genes in Caco-2 cell line.
Hello Joseph, thank you for your feedback. I would like to ask you which Akkermansia product you are currently taking. Is it the 500 million CFU Akk or the Pendulum GLP-1? Thank you.
@sml491010 This is what I take now. I started with the first akkermansia only product from pendulum. I then switched to their GLP product before moving to this one. I’m very satisfied.
