https://x.com/davidasinclair/status/1841206597781262788
Rest in peace.
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Rest in peace Dr. Misha Blagoskonny! Thank you for your work!
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First Dr. Green, now Blagoskonny. RIP. Much respect for all the work and the passion to help humanity in the quest to age better.
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Dang. Too soon. Thanks for all your work! RIP
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Amazing researcher.
Blagosklonnyâs article on rapamycin for longevity over 4 years ago gave me the motivation to start rapamycin. And, I used it as evidence to convince my Personal Physician to start me on a rapamycin prescription.
Link: Rapamycin for longevity: opinion article - PMC
Still a widely published piece⌠and comes up at the top of a Google search on rapamycin.
He probably gave me 20 -25 more healthy years. Already benefited from the last 4 years immensely. Thanks Misha.
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Very sad news. Dr Green and Mikhail Blagosklonny connected by the common denominator (Rapamycin), passed just a few days apart.
Nothing can beat cancer. So discouraging.
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They found a mass in his lung in 1991 and 8 years later it had no change. He proposed the cancer was slowed by taking tapa but there is no way to definitely know
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Another great passes on. We all know that Rapamycin cannot eliminate cancer, but it is conjectured that it can slow it down. I know that Dr. B was trying a lot of alternative therapies to try and get rid of his cancer, but in the end they just werenât effective. Cancer is one tough nut to crack.
R.I.P. Dr. B. Your optimism and insightful thoughts will surely be missed. We honor your memory here.
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Dr green and now misha at fairly average agesâŚwe sure this rapamycin thing is working out? N=2âŚbutâŚ.just saying
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Classically this is unhealthy user bias. When people have a disease they tend to look for ways to manage it, often by using medication or supplements. But because their health is compromised, they tend to have higher morbidity and mortality than those who do not use that medication or supplement. If you surveyed all big bandage users, youâd find more wounds among them than those who donât use bandages in that period of time. This doesnât mean bandages cause wounds, itâs a case of reverse causality.
But if we are talking about the PR aspect wrt. rapamycin, then yes, this is a big negative to have a prominent advocate and user pass away prematurely. But the health context matters, speaking of which, I hope Matt Kaeberlein is hale and hearty!
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So true.
We all work hard to do all we can for health span and longevity but cancer can nullify all of that.
It frequently comes to mind at work when I see a young otherwise healthy person with cancer.
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rip.
one day we will conquer cancer, rage against the dying of the light
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Sometimes patients die from complications related to classical cancer treatments. We do not know which chemotherapy or radiotherapy they received or which surgeries they had; all of these have serious mortality effects.
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Only 2 things in life are guaranteed, death and taxes.
So far no one has cheated death.
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Always enjoyed reading his papers and posts on twitter.
He was a big part of why we started Rap.
Condolences to his family and co-workers.
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a really good pieceâŚ
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whatâs the denominator? nature is stochastic to a certain degree. i have a family history of cancer. one exampl, a relative of mine, who is by all conventional âresearchâ and âhealthâ consensus probably one of the top healthiest people of her age group in the world. a doctor who lived remotely with native tribes out in the backcountry, eating only wild fish and game (wild salmon, moose, caribou, halibut), wild berries, hiking all the time, drinking pure spring water, does yoga and fitness. now in her 70âs, she has cancer. no environmental history either.
you could argue that the âeat healthy and exerciseâ dogma ainât working out so well. n = 1 (and more with my family) alreadyâŚ
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FWIW, Iâve seen scientific estimates that about 30% or so of all cancers are beyond your control. So even if you get all your ducks in a row, you still have a 30% chance of getting cancer. As the wise saying goes, âit is better to be lucky than goodâ. To be fair, Blagoskonny wasnât a paragon of getting everything right healthwise, since apparently he was a persistent smoker at some point. Tobacco products are known powerful carcinogens among other deleterious effects. No judgement on that and we donât know if his smoking was connected with the cancer, but when you roll the dice, sometimes it comes up bad.
In any case, just because cancer cannot be prevented by anything currently under our control doesnât mean we should therefore not take control of that which we do have access to. Itâs the best we can do until science solves cancer, hopefully soon.
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Of course. Iâm more just making light of the ironyâŚ.
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yea i donât think twice about physicians/researchers whose personal lifestyle may not line up with their focus area. itâs not unobvious that plenty of researchers and doctors donât take care of their own health. itâs one reason i left the field professionally-I couldnât maintain the same level of fitness/health I expected from myself working in that profession (being on call one of the worst).
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