Paper: Small HDL Particles and Physical Activity as Key Determinants of Longevity of Older Adults

https://www.thelancet.com/action/showPdf?pii=S2352-3964(22)00474-1

Findings
As few as 8-15 variables predicted longevity at 2-, 5- and 10-years with predictive performance (area under receiver operator characteristic curve) of 0¢76 (95% CIs 0¢69, 0¢83), 0¢76 (0¢72, 0¢81) and 0¢66 (0¢61, 0¢71), respectively. Numbers of small high-density lipoprotein particles, younger age, and fewer pack years of cigarette smoking were the strongest determinants of longevity at 2-, 5- and 10-years, respectively. Physical function was a prominent predictor of longevity at all time horizons. Age and cognitive function contributed to predictions at 5 and 10 years. Age was not among the local 2-year prediction variables (although significant in univariable analysis), thus establishing
that age is not a direct cause of 2-year longevity in the context of measured factors in our data that determine longevity.

I find these sorts of papers quite interesting. Although there are a number of models (such as the Levine algorithm) that give a biological age based upon biomarkers there are biomarkers that are consistent.

For example creatinine crops up in many predictions. Interestingly if someone is about to die in the next 2 years (according to this study) how old they are does not affect their predictive mortality materially compared to all of the markers.

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Looks like there is a better lipid test than the one I have been getting. Of course, it costs over twice as much and I don’t think my PP is going to prescribe it.

This is a test Walk-In Lab that offers both LDL and HDL particles and numbers:

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Is there any evidence that you can change your HDL, or that changing it helps?