In mice but interesting…
Short-term overnutrition induces glucose intolerance and insulin resistance and impairs insulin’s ability to suppress WAT lipolysis
Male C57BL/6 mice fed an HFD for either 3 or 10 days displayed increased adiposity, even though body weight gain did not reach statistical significance (Figures S1A and S1B). Blood glucose was increased in the fasting and fed state (Figure S1C) despite hyperinsulinemia (Figure S1D). Glucose tolerance and insulin sensitivity were impaired after HFD feeding (Figures S1E and S1F), consistent with insulin resistance, as previously reported.31,32
Article about the paper:
Partial paper (snippets):
https://www.sciencedirect.com/science/article/abs/pii/S1550413124003760