P-16 protein Scandal - decades of anti-aging research

[CronosTempi]

This is insane. You can throw most senescent cell research and supplements such as fisetin into the garbage. Glad I never fell for the hype.

The Anti-Aging Supplement Everyone Took Never Worked

- YouTube

[Virilius]

Always knew fisetin was worthless despite how much people hyped up the mEcHaNiSmS. Well, turns out the mechanism wasn’t there either.

[qBx123Yk]

The genetic test seems solid for p16INK detection, but the antibody one is suspect to say the least. Hilarious that some of these papers out here that use the antibody test have published positive results.

[Cole]

Protein name confusion created antibody mix-up affecting hundreds of papers

https://www.science.org/content/article/protein-name-confusion-created-antibody-mix-affecting-hundreds-papers Hundreds of scientists who study cancer and aging have made an easily avoidable but significant mistake, deploying the wrong antibody to test for a key protein, according to a researcher who exposes errors in the biomedical literature. Instead of antibodies that recognize p16INK4a, a tumor-suppressing protein that may also promote aging, these researchers used antibodies that tag the similarly named protein p16-ARC, which helps shape the cell’s molecular skeleton. The gaffe appears in more than 300 papers, including some published by top journals such as Nature, Nature Medicine, Cancer Cell, eLife, and Science Advances, reports Sholto David, a molecular biologist at the U.K. biotech OXB and a part-time error hunter. David’s latest revelations, posted on 2 June on the blog For Better Science, have sent researchers digging through old lab notebooks and, in at least one case,…

[argonaut]

Look deeply into my eyes. Let all your tension float away. Your eyelids are getting heavy.

- YouTube