Sleep apnea and orthostatic hypotension or reduction in blood flow upon standing might be hidden dangers then.
I’ll call them “micro hypoxic events”, and in late life they could happen 1000x+ times, who knows.
Surprisingly sleep apnea confers a longevity benefit. I’ll merge these two threads to avoid repeating myself…
If it’s the 2009 citation: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2869.2009.00754.x
The observed benefit was in elderly (and in the paper they cite younger demographics have increase in mortality), likewise simply being in the group of testing for sleep apnea trended towards a decrease in mortality by 30%, with RDI below 20 same as asymptomatic, presumably what they’re comparing with. Might be residual confounding there, but they did adjust for some confounding factors. Since it’s a relatively small study they can’t adjust for too many.
The altitude/hypoxic ranges in the mouse article for chronic exposure to 13-15% seems to agree with the paper below. Moderate altitudes are protective while high altitude can be damaging.
Consequently, it could be speculated that living at higher altitude, and therefore in hypoxic conditions, accelerates aging. This assumption is indeed supported by evidence from populations residing at very high altitudes (>3,500 m). In contrast, accumulating evidence suggests that living at moderate altitudes (1,500–2,500 m) is protective rather than injurious, at least for some body systems.
Yes, it’s the 2009 study, cited in this review: Oxygen, hypoxia and hyperoxia - #77 by adssx
Another paradox: several papers showed that intermittent hypoxia exposure seems to improve sleep apnea symptoms: Effects of Intermittent Hypoxia Protocols on Cognitive Performance and Brain Health in Older Adults Across Cognitive States: A Systematic Literature Review 2024
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@John_Hemming: could roxadustat (approved for anemia) be hypoxia in a pill? See: Hypoxia-inducible factor prolyl hydroxylase inhibitors for anaemia in chronic kidney disease: a clinical practice document by the European Renal Best Practice board of the European Renal Association 2024
It reads as such, but I would need to spend some time reading more than glancing at that paper.