osthol applied at 10 uM dose for 6 hours (adj. p-value = 0.0038). Interestingly, osthol has
374 been shown to demonstrate anti-inflammatory effects by blocking the activation of NF-κB and
375 MAPK/p38 pathways (57). In addition, osthol prevents accumulation of advanced glycation end
376 products (AGE) via the induction of Klotho expression (58
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Interesting compound, will need a bit of “help” to be truly effective.
Osthol (osthole), known as a neuroprotective drug, has shown potent anticancer activity. However, the potential clinical application of osthol is limited due to its low water solubility and low bioavailability. Polybutyl cyanoacrylate (PBCA) has been widely used to improve the solubility of drugs with poor water solubility.