People with “young” brains and immune systems outlive those with old ones
You could be 45 on paper but 60 in your kidneys.
Turns out, your organs have birthdays of their own — and how well they’re faring may set the pace for your health, researchers report July 9 in Nature Medicine. Using data from nearly 45,000 people, scientists developed a blood-based test to estimate the biological age of 11 organs, providing a measure of how healthy or worn down each organ is. When a person has an organ substantially “older” than their actual age, disease risks tied to that organ surge. Conversely, extremely youthful brains and immune systems are linked to living longer, the results suggest.
“The fact that [the researchers] can create an organ age using proteins — and use it to predict diseases that you would expect to be predicted from that organ — is quite amazing,” says Sarah Harris, a molecular biologist at the University of Edinburgh who was not involved in the study.
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Open Access Paper:
H. Oh et al. Plasma proteomics links brain and immune system aging with healthspan and longevity. Nature Medicine. Published online July 9, 2025. doi: 10.1038/s41591-025-03798-1.