Orforglipron - A New small-molecule GLP-1 agonist achieves similar effects as injectable peptide drug, Ozempic, in clinical trial

All over the internet, just search for orforglipron.

An organic molecule will be easier to produce, ship and store vs a peptide. A once daily pill is also a lot easier for patients vs an injection.

Here’s Lilly’s press release

https://investor.lilly.com/news-releases/news-release-details/lillys-oral-glp-1-orforglipron-demonstrated-statistically

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This is the future! People will take them like statins, I suspect. The next big blockbuster drug for Lilly.

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I agree…their stock is up 14-15% today. It’s apparently licensed to them by a small Japanese Pharma company who developed it. I bet they are celebrating as well. :slightly_smiling_face:

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Definitely an exciting development…

The drug, orforglipron, is a GLP-1, a class of drugs that have become blockbusters because of their weight-loss effects. But the GLP-1s on the market now are expensive, must be kept refrigerated and must be injected. A pill that produces similar results has the potential to become far more widely used, though it is also expected to be expensive.

Lilly said it would seek approval from the Food and Drug Administration later this year to market orforglipron for obesity and early in 2026 for diabetes. Industry analysts expect the drug to win approval sometime next year and to eventually become a major blockbuster. Eli Lilly is not expected to announce a price for the drug until after it wins approval.

Full article:

Also, does not have the dosing restrictions of Rybelsus, (Novo oral GLP-1) Required to take in morning on empty stomach with 4 oz water and wait 30 min for any food or liquid. Goodbye morning breakfast or coffee. Orforglipon has no such limitations. I can buy at pharmacy here in Spain: RYBELSUS 14 MG 30 COMPRIMIDOS 132,77 Euros. Only approved for diabetes, but many using for weight loss.

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