I’ve been lurking for a bit and now decided to officially join your forum.
I’m interested in rapamycin for a few reasons: for my dog who has spinal disease, for longevity in particular the potential fertility benefits, but also for aesthetic reasons (don’t hate me! 
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My question is whether oral or topical rapamycin for skin health is best? By skin health I mean things like sun damage, wrinkles, collagen and elastin etc.
Is there more evidence for topical preparations for specifically skin anti-aging? I saw someone on here saying they’ve stopped applying it topically because of potential negative effects.
Have any of you taking it by mouth seen aesthetic benefits? I couldn’t see this listed as a positive side effect from the survey (in FAQs).
At the moment I’m leaning towards taking it in tablet form because I am interested in the longevity effects too so that just makes sense.
I’m doing my best reading through papers and scouring the posts on here, and I realise there aren’t really many answers - but I’d love to know what you all think!