Ora Biomedical update

From Mitchel Lee of Ora Biomedical

“As a token of our gratitude, I wanted to pass along a hot-off-the-WormBot result that is very exciting. Attached you will find a recent result for ORB-1284. This is a newly identified lifespan-extending compound we identified, and, in this experiment, it produced a whopping 71% increase in median lifespan relative to controls! Feel free to post this to your social media or spread the word as you see fit! And please make sure to give Ora Biomedical a shout out when you do!”

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He also said:
"Hello Million Molecule Challenge Sponsors!

I wanted to send a quick email to thank you for your support and give you a quick update.

First, thank you for your vision and support of the Million Molecule Challenge! Longevity Medicine is on the cusp of ushering in a health revolution that will result in humans and the animals we love living the longest, healthiest lives possible. For that to happen, we first need to do the work of combing through chemical space to find the very best interventions that target aging. This is why your support of the Million Molecule Challenge is so important.

So again, on behalf of everyone at Ora Biomedical, thank you for playing a role in advancing longevity science!

We are currently putting data together for the first sponsored interventions! We are on track to start sending out sponsorship results by the end of January and have our V1 leaderboard up in February. Completing sponsored studies is occurring while we are finalizing financing to fuel our operations. Stay tuned to Ora Biomedical on social media for a big announcement on funding in the coming days! This financing, among other things, will allow us to expedite sponsored studies and return data much faster! Thank you for your patience as we move into this new chapter at Ora Biomedical."

Great to hear!

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Exciting and Very cool! But what is ORB-1284?

And what animals are we talking about here? Mice? Fruit flies? Worms?

It’s worms. C. Elegans.

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They probably won’t say what that actual compound is until they’ve decided whether to patent it or not, and even then wait until a patent is filed. This is how they hope to build a business after all… taking these compounds to market.

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Problem here is short-lived control group - control grouped lived for 12 days - by average C Elegans live about 21 days

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I don’t see ORB on the leaderboard, was it omitted intentionally?

One thing I notice with these tests is that many that have done well in the ITP (ie Rapa + Acarbose) don’t seem to extend worm life at all.