Hi. I’m a longtime life extension advocate/practitioner and short time lurker of this excellent user group. I’m 52, male. In the past I practiced moderate to extreme calorie restriction for 7 years following Walford’s CRON program with excellent health results but diminishing quality of life (basically a contraction in my emotional “range”).
A little over 2 years ago I started adding Rapamycin to my “stack” and never looked back. Despite 2 bacterial infections in the first year and infrequent mouth sores my experience with it has been extremely good. I now purchase all of my RX from Maulik (who I found from this user group – Thanks!) and save a ton by doing it! I recently have been trying to understand how to optimize my Rapa protocol. I have done a blood test at the end of the week to ensure there is no Rapa in my blood. Since then I have 1) added Capsugel DRcaps to take my 4 weekly pills and 2) added grapefruit on day 1 and day 2, (in addition to day 0 prior to the Rapamycin). The intent is to get a higher initial dose and keep it in my blood longer. I will test my blood again soon to ensure that I have no measurable rapamycin on day 6 of the week and thus likely no TORC2 impact. The blood test from gethealthspan.com is reasonably priced at $25.
I did 23andme years ago and recently discovered the free site geneticgenie.org. If you download your raw 23andme data to the site it will give you a nice report on your genetic profile that is much more extensive than 23andme. In my case I discovered I have a 70% reduction in folate/b12 methylation due to a homozygous MTHFR gene. Of particular interest to this group: the free report will also evaluate your genetic response to drugs, and among those evaluated is tacrolimus, which could provide insight into your sirolimus response based on the similar structure and binding of the 2 drugs.
I appreciate the collective knowledge in this group and I humbly submit my “stack” for your feedback (I try to follow the gethealthspan autophagy/AMPK cycling protocol for the 3 Rapa days and 4 non-Rapa days)…
| RX: Sirolimus in DR Caps (Pure Capsules) | 4mg/wk w grapefruit (~12mg) |
|---|---|
| RX: Metformin | 500mg |
| RX: Empagliflozin | 10mg |
| RX: Victoza | 0.18mg (3 clicks) |
| RX: Tadalafil | 5mg |
| RX: Acarbose | 50mg x2 |
| RX: Rosuvastatin | 2.5mg |
| B3 (Niacinamide)- 3 RAPA days) | 500mg |
| Quercetin - (3 RAPA days) | 500mg |
| Caylon Cinnamon - (3 RAPA days) | 600mg x 2 |
| Berberine w/MCT- (4 non RAPA days) | 400mg |
| “Curcubrain”- (4 non RAPA days) | 400mg |
| Milk thistle- (4 non RAPA days) | 250mg |
| Ginger root- (4 non RAPA days) | 500mg |
| Pterostilbene- (4 non RAPA days) | 100mg |
| Grape seed extract- (4 non RAPA days) | 400mg |
| Ashwagandha - (4 non RAPA days) | 300mg |
| EGCG - (4 non RAPA days) | 400mg |
| POWDER Creatine | 5000mg |
| POWDER Glycine | 3000mg |
| POWDER TMG | 1000mg |
| POWDER Psyllium husk | 8gm |
| POWDER Taurine | 5000mg |
| POWDER Carnosine | 250mg |
| Spermidine drops | 20mg |
| Hyaluronic Acid +C +Biotin | 200mg/25mg/5mg |
| SAM e | 200mg |
| CoQ10 / PQQ | 100mg |
| Multivitamin | 1 pill |
| Carlson very finest (refrigerate) | 1/2 tsp: 800EPA/500DHA |
| Magnesium Glycinate w/bioperene | 200mg |
| Magnesium Malate | 120mg |
| N-Acetyl L-Cysteine (NAC) | 1200mg |
| Ultra Vitamin K | 1000mcg |
| Mushroom Complex | 500mg |
| Calcium AKG | 500mg |
| Luteolin | 100mg |
| D3 | 2k/5k IU (summer/winter) |
| Odorless Garlic | 1,200mg |
| Pine Bark Extract | 300mg |
| Asprin | 81mg |
| Alpha Lipoic Acid | 333mg |
| Saffron | 88mg |
| Methyl Folate / B12 | 640mcg/500mcg |
| Glocosamine/Chondroitin/MSM | 1460/1600/400 |
| FOS | 1000mg |
| Astaxanthin | 12mg |
| Neuro Support Complex | 500mg |
| Chelated Iron (rapa reduces uptake) | 18mg |
| Vanadium/Chromium | 2mg/200mcg |
| Sulforaphane | 400mcg |
| Melatonin sustained release | 0.3mg |
| Melatonin | 10mg |
| Chlorella | 500mg |
| Cilantro | 450mg |
| l-optizinc | 30mg |
| C w/citris biofl/Rutin | 1000/100/25mg |
| Natto | 100mg |
| Tart Cherry (take in pm - melatonin) | 300mg |
| Aged Garlic Extract | 60mg |
| Rhodiola Rosea | 250mg |
| Citrus Bergamot | 700mg |
| Peppermint | 500mg |
| Capsaicin | 350mg |
| Lithium Orotate | 5mg (lithium) |