Omega-3 Supplements May Increase Risk of Cognitive Decline, Scientists Warn

There are also these interesting CVD RCTs comparing EPA to DHA:

Said otherwise, by 2030 we should have a definite answer to the benefits of EPA vs DHA…

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I’ve just checked that paper, the DHA-rich oil is not only doing worse than the EPA-rich one but it’s almost doing worse than the placebo…

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@adssx - you know how companies pay researchers to bias their studies in favor of their drug/supplement, or have conflicts of interest (ahem, Bill Harris). Well, I think soon the opposite may happen with the companies selling fishoil - they may have to pay you off $$$ big time, because you are destroying their business, lol :rofl::rofl::rofl::rofl:!!!

If one day Antoine suddenly says “never mind, DHA is the healthiest thing around, take all you can!”, and also coincidentally moves into a newly purchased big mansion in Belgravia, you will know what happened :stuck_out_tongue_winking_eye::rofl:

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Same, I keep thinking about Kaiberlein’s repeated warnings that supplements are real medicine, and not necessarily harmless. If we aren’t deficient in something, we shouldn’t take it just because some influencer touted it’s benefits. And unknown interactions could also be less than beneficial.

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I think the idea is only taking things you are deficient in is simple minded and inadequate. Something that an influencer would say to a non scientific audience

The human body doesn’t require 124 ug of a substance daily and that is the perfect number. This rabbit hole has been debunked time and time again. Vitamin D deficiency causes rickets but that doesn’t mean the level of vitamin D after preventing rickets doesn’t correlate with 1000 other disease states. And it doesn’t mean you can fix things by taking a pill either.

Arguably, most westerners are deficient in Omega 3s. Why? Because there is a marked difference in dementia rates and CVD based on blood levels. That deficiency doesn’t make omega 3 supplements a slam dunk either.

What defines a deficiency state is 100% in the eye of the beholder. The general term “deficiency” mostly just means avoiding a specific disease state when we do not understand what molecules impact health beyond these specific disease states. Literally no one thinks the purpose of vitamin D in the body is just to prevent rickets. There are vitamin d receptors in almost every tissue yet the defined deficiency states are bone related.

The fact is there are RCTs showing impact of various supplements beyond deficiency and disease states. Are some of these industry financed and questionable? Sure. But dismissing 100% of these studies because some are questionable is not the right answer either.

No one has truly defined most deficiency states so we are all flying somewhat blind except for rickets and beriberi and the like. Health is a continuum not strictly an avoidance of disease states.